Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study
Background: Skin warts are benign tumors caused by infection of keratinocytes with human papillomavirus (HPV), visible as well-defined hyperkeratotic protrusions. Recently, immunotherapy is emerging as a new modality in the treatment of viral warts. Immunotherapy using Vitamin D3 is being tried wide...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Clinical Dermatology Review |
| Subjects: | |
| Online Access: | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2023;volume=7;issue=3;spage=272;epage=276;aulast=Sharma |
| _version_ | 1827783368832450560 |
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| author | Geeta Sharma Shilpi Sharma |
| author_facet | Geeta Sharma Shilpi Sharma |
| author_sort | Geeta Sharma |
| collection | DOAJ |
| description | Background: Skin warts are benign tumors caused by infection of keratinocytes with human papillomavirus (HPV), visible as well-defined hyperkeratotic protrusions. Recently, immunotherapy is emerging as a new modality in the treatment of viral warts. Immunotherapy using Vitamin D3 is being tried widely for the treatment of warts. It is based on enhancing the immune system to achieve an HPV-targeted immune reaction. Objective: The objective of this study was to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of viral warts. Materials and Methods: This was a hospital-based longitudinal study of 55 patients with viral warts. 0.5 ml Vitamin D3 solution (600,000 IU, 15 mg/ml) was injected in the base of the wart. A maximum of four warts per session were injected at 2-week intervals until resolution or for a maximum of four treatment sessions. The clinical assessment was done by pre- and posttreatment photographic comparison at baseline, before each treatment session, and after the completion of treatment. Results: Thirty-five patients (63.63%) showed complete clearance, 15 patients (27.27%) showed partial clearance, and 5 patients (9.09%) patients showed no improvement. No significant side effects were observed except for pain and mild swelling at the site of injection. Conclusion: Intralesional Vitamin D3 immunotherapy seemed to be an effective, safe, inexpensive treatment with minimal side effects. |
| first_indexed | 2024-03-11T15:46:38Z |
| format | Article |
| id | doaj.art-fd069ba2a3464c4bb2328f0c7a9d0d07 |
| institution | Directory Open Access Journal |
| issn | 2542-551X 2542-5528 |
| language | English |
| last_indexed | 2024-03-11T15:46:38Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj.art-fd069ba2a3464c4bb2328f0c7a9d0d072023-10-26T06:14:05ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282023-01-017327227610.4103/cdr.cdr_36_22Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational studyGeeta SharmaShilpi SharmaBackground: Skin warts are benign tumors caused by infection of keratinocytes with human papillomavirus (HPV), visible as well-defined hyperkeratotic protrusions. Recently, immunotherapy is emerging as a new modality in the treatment of viral warts. Immunotherapy using Vitamin D3 is being tried widely for the treatment of warts. It is based on enhancing the immune system to achieve an HPV-targeted immune reaction. Objective: The objective of this study was to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of viral warts. Materials and Methods: This was a hospital-based longitudinal study of 55 patients with viral warts. 0.5 ml Vitamin D3 solution (600,000 IU, 15 mg/ml) was injected in the base of the wart. A maximum of four warts per session were injected at 2-week intervals until resolution or for a maximum of four treatment sessions. The clinical assessment was done by pre- and posttreatment photographic comparison at baseline, before each treatment session, and after the completion of treatment. Results: Thirty-five patients (63.63%) showed complete clearance, 15 patients (27.27%) showed partial clearance, and 5 patients (9.09%) patients showed no improvement. No significant side effects were observed except for pain and mild swelling at the site of injection. Conclusion: Intralesional Vitamin D3 immunotherapy seemed to be an effective, safe, inexpensive treatment with minimal side effects.http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2023;volume=7;issue=3;spage=272;epage=276;aulast=Sharmaimmunotherapyvitamin d3warts |
| spellingShingle | Geeta Sharma Shilpi Sharma Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study Clinical Dermatology Review immunotherapy vitamin d3 warts |
| title | Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study |
| title_full | Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study |
| title_fullStr | Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study |
| title_full_unstemmed | Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study |
| title_short | Efficacy of intralesional immunotherapy with Vitamin D3 injection in cutaneous warts: A clinical observational study |
| title_sort | efficacy of intralesional immunotherapy with vitamin d3 injection in cutaneous warts a clinical observational study |
| topic | immunotherapy vitamin d3 warts |
| url | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2023;volume=7;issue=3;spage=272;epage=276;aulast=Sharma |
| work_keys_str_mv | AT geetasharma efficacyofintralesionalimmunotherapywithvitamind3injectionincutaneouswartsaclinicalobservationalstudy AT shilpisharma efficacyofintralesionalimmunotherapywithvitamind3injectionincutaneouswartsaclinicalobservationalstudy |