IL-17/Notch1/STAT3 Pathway Contributes to 5-Fluorouracil-Induced Intestinal Mucositis in Rats: Amelioration by Thymol Treatment

IL-17/Notch1/STAT3 Pathway Contributes to 5-Fluorouracil-Induced Intestinal Mucositis in Rats: Amelioration by Thymol Treatment

5-Fluorouracil (5-FU) is an anticancer drug with intestinal mucositis (IM) as a deleterious side effect. Thymol is a monoterpene phenol which has been reported to possess an antioxidant and anti-inflammatory activity versus 5-FU-induced IM. The Notch pathway affects multiple cellular activities, suc...

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Bibliographic Details
Main Authors: Amira M. Badr, Layla A. Alkharashi, Iman O. Sherif, Alaa A. Alanteet, Hind N. Alotaibi, Yasmen F. Mahran
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceuticals
Subjects:
5-fluorouracil
intestinal mucositis
thymol
Notch/STAT3 pathway
Online Access:https://www.mdpi.com/1424-8247/15/11/1412

Internet

https://www.mdpi.com/1424-8247/15/11/1412

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