MicroRNAs as Potential Biomarkers in Gynecological Cancers
MicroRNAs are non-coding transcripts that, thanks to the ability to regulate the mRNA of target genes, can affect the expression of genes encoding tumor suppressors and oncogenes. They can control many important cellular processes, including apoptosis, differentiation, growth, division, and metaboli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1704 |
| _version_ | 1797596000556154880 |
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| author | Joanna Miśkiewicz Aleksandra Mielczarek-Palacz Joanna Magdalena Gola |
| author_facet | Joanna Miśkiewicz Aleksandra Mielczarek-Palacz Joanna Magdalena Gola |
| author_sort | Joanna Miśkiewicz |
| collection | DOAJ |
| description | MicroRNAs are non-coding transcripts that, thanks to the ability to regulate the mRNA of target genes, can affect the expression of genes encoding tumor suppressors and oncogenes. They can control many important cellular processes, including apoptosis, differentiation, growth, division, and metabolism. Therefore, miRNAs play an important role in the development of many cancers, including gynecological cancers. Ovarian cancer, endometrial cancer, cervical cancer, and vulvar cancer are the most common cancers in women and are a frequent cause of death. The heterogeneity of the pathogenesis of these gynecological diseases makes the diagnostic process a significant obstacle for modern medicine. To date, many studies have been carried out, in which particular attention has been paid to the molecular pathomechanism of these diseases, with particular emphasis on miRNAs. To date, the changed profile of many miRNAs, which influenced the promotion of proliferation, migration, invasion processes and the simultaneous inhibition of programmed cell death, has been proven many times. Detailed understanding of the molecular effects of miRNAs in the above-mentioned gynecological cancers will enable the development of potential predictive and prognostic biomarkers, as well as the optimization of the diagnostic process. |
| first_indexed | 2024-03-11T02:44:21Z |
| format | Article |
| id | doaj.art-fd0862d0ffd84eec87d15e9c54eb63c6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:44:21Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fd0862d0ffd84eec87d15e9c54eb63c62023-11-18T09:27:01ZengMDPI AGBiomedicines2227-90592023-06-01116170410.3390/biomedicines11061704MicroRNAs as Potential Biomarkers in Gynecological CancersJoanna Miśkiewicz0Aleksandra Mielczarek-Palacz1Joanna Magdalena Gola2Department of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, PolandDepartment of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, PolandDepartment of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, PolandMicroRNAs are non-coding transcripts that, thanks to the ability to regulate the mRNA of target genes, can affect the expression of genes encoding tumor suppressors and oncogenes. They can control many important cellular processes, including apoptosis, differentiation, growth, division, and metabolism. Therefore, miRNAs play an important role in the development of many cancers, including gynecological cancers. Ovarian cancer, endometrial cancer, cervical cancer, and vulvar cancer are the most common cancers in women and are a frequent cause of death. The heterogeneity of the pathogenesis of these gynecological diseases makes the diagnostic process a significant obstacle for modern medicine. To date, many studies have been carried out, in which particular attention has been paid to the molecular pathomechanism of these diseases, with particular emphasis on miRNAs. To date, the changed profile of many miRNAs, which influenced the promotion of proliferation, migration, invasion processes and the simultaneous inhibition of programmed cell death, has been proven many times. Detailed understanding of the molecular effects of miRNAs in the above-mentioned gynecological cancers will enable the development of potential predictive and prognostic biomarkers, as well as the optimization of the diagnostic process.https://www.mdpi.com/2227-9059/11/6/1704miRNAgynecological cancersbiomarkers |
| spellingShingle | Joanna Miśkiewicz Aleksandra Mielczarek-Palacz Joanna Magdalena Gola MicroRNAs as Potential Biomarkers in Gynecological Cancers Biomedicines miRNA gynecological cancers biomarkers |
| title | MicroRNAs as Potential Biomarkers in Gynecological Cancers |
| title_full | MicroRNAs as Potential Biomarkers in Gynecological Cancers |
| title_fullStr | MicroRNAs as Potential Biomarkers in Gynecological Cancers |
| title_full_unstemmed | MicroRNAs as Potential Biomarkers in Gynecological Cancers |
| title_short | MicroRNAs as Potential Biomarkers in Gynecological Cancers |
| title_sort | micrornas as potential biomarkers in gynecological cancers |
| topic | miRNA gynecological cancers biomarkers |
| url | https://www.mdpi.com/2227-9059/11/6/1704 |
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