The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms
Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-08986-z |
| _version_ | 1819127377296359424 |
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| author | Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo |
| author_facet | Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo |
| author_sort | Xiaoling Zhuge |
| collection | DOAJ |
| description | Abstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p < 0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs. |
| first_indexed | 2024-12-22T08:10:57Z |
| format | Article |
| id | doaj.art-fd09f5a60abb4a11bf8930cdcb0772c9 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-22T08:10:57Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-fd09f5a60abb4a11bf8930cdcb0772c92022-12-21T18:33:01ZengBMCBMC Cancer1471-24072021-11-012111910.1186/s12885-021-08986-zThe association between serum ferritin levels and malignant intraductal papillary mucinous neoplasmsXiaoling Zhuge0Hao Zhou1Liming Chen2Hui Chen3Xiao Chen4Chuangen Guo5Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Affiliated Hospital of Nanjing University of Chinese MedicineDepartment of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiology, the Affiliated Hospital of Nanjing University of Chinese MedicineDepartment of Radiology, the First Affiliated Hospital, Zhejiang University School of MedicineAbstract Background Serum ferritin levels are elevated in many malignancies. In this study, we showed the performance of serum ferritin in identifying malignant intraductal papillary mucinous neoplasms (IPMNs). Methods A total of 151 patients with pathologically confirmed IPMNs were enrolled. Serum tumor biomarker (carbohydrate antigen 19–9 (CA19–9) and carcinoembryonic antigen (CEA)) levels and serum ferritin levels were recorded. Lesion location, tumor size, diameter of the main pancreatic duct (MPD), mural nodule, and IPMN type, were collected from imaging examinations. IPMNs with high grade dysplasia and associated invasive carcinoma were considered malignant IPMNs. Results Serum ferritin levels in patients with malignant IPMNs were higher than those in patients with nonmalignant IPMNs (p < 0.05). Serum ferritin was an independent factor for the occurrence of malignant IPMNs (odds ratio (OR) = 1.18, 95% confidence interval (CI):1.01–1.39). A similar trend was found between high serum ferritin (> 149 ng/ml) and malignant IPMNs (OR = 5.64, 95% CI:1.78–17.92). The area under the curve (AUC) of serum ferritin was higher than that of CEA and CA19–9 in identifying malignant IPMNs (AUC = 0.67 vs. AUC = 0.58, 0.65). The combination of serum ferritin with IPMN type showed a similar performance to MPD diameter and the combination of serum CA19–9 with IPMN types in identifying malignant IPMNs (AUC = 0.78 vs. AUC = 0.79, 0.77) and invasive carcinoma (AUC = 0.77 vs. AUC = 0.79, 0.79). Conclusions Elevated serum ferritin is a factor associated with malignant IPMNs. Serum ferritin may be a useful marker for identifying malignancy in IPMNs.https://doi.org/10.1186/s12885-021-08986-zIntraductal papillary mucinous neoplasmsFerritinMalignancyInvasive carcinoma |
| spellingShingle | Xiaoling Zhuge Hao Zhou Liming Chen Hui Chen Xiao Chen Chuangen Guo The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms BMC Cancer Intraductal papillary mucinous neoplasms Ferritin Malignancy Invasive carcinoma |
| title | The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| title_full | The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| title_fullStr | The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| title_full_unstemmed | The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| title_short | The association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| title_sort | association between serum ferritin levels and malignant intraductal papillary mucinous neoplasms |
| topic | Intraductal papillary mucinous neoplasms Ferritin Malignancy Invasive carcinoma |
| url | https://doi.org/10.1186/s12885-021-08986-z |
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