Utility of MRI in diagnosis of molecular subtypes of breast cancer
Background: Breast cancer is a collection of diseases defined by distinct pathological (e.g., ductal, lobular, mucinous) and molecular characteristics (e.g., ER and PR, HER2 amplification, and more recently transcriptome-based classifications such as luminal and basal cancers). Molecular subtyping i...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2022-01-01
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| Series: | SVU - International Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://svuijm.journals.ekb.eg/article_199523.html |
| _version_ | 1818049754209189888 |
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| author | Ebtsam Ahmed Mohammed* Mohamed Tharwat Mahmoud Solyman Nagham Nabil Omar Nahla Mohamed Ali Hasan |
| author_facet | Ebtsam Ahmed Mohammed* Mohamed Tharwat Mahmoud Solyman Nagham Nabil Omar Nahla Mohamed Ali Hasan |
| author_sort | Ebtsam Ahmed Mohammed* |
| collection | DOAJ |
| description | Background: Breast cancer is a collection of diseases defined by distinct pathological (e.g., ductal, lobular, mucinous) and molecular characteristics (e.g., ER and PR, HER2 amplification, and more recently transcriptome-based classifications such as luminal and basal cancers). Molecular subtyping is beneficial for the diagnosis and individualized treatment of breast cancer.MRI is a supplemental technique to mammography and ultrasonography for the evaluation of breast lesions and to predict molecular subtypes of breast cancer. Studies have highlighted the value of DCE-MRI in reflecting the anatomic and functional properties of tumors and facilitating treatment.
Objectives: The aim of this work was to assess the utility of MRI as an accurate method for detection of molecular subtypes of breast cancer.
Patients and Methods: a retrospective clinical study of 2-years enrollment duration. The study was conducted at Radiology Department, Assuit University Hospitals on 50 lesions, patient age ranging from 23 to 66 years old with mean age was (46.9 ± SD) years. MR imaging studies were performed using a 1.5 T Magnetom Vision scanner with dedicated bilateral phased-array breast coil (Siemens, Erlangen, Germany). MRI sequences were 1. Axial T1WI. 2. Axial T2WI. 3. Axial STIR. 4. Axial DWI and ADC. 5. DCE-MRI.
Results: The study included 50 lesions; 21 lesions were Luminal A, 15 lesions were Luminal B, 10 lesions were HER2+, and 4 lesions were TN. Histopathology 39 lesions were IDC-NOS, 1 lesion was IDC (medullary type), 7 lesions were mixed pathology IDC + DCIS, and 3 lesions were ILC. As regard the correlation between the histopathological type and grade, both were specific in differentiation between the molecular subtypes. According to the MRI findings it was found that T2 Intratumoral signal intensity, STIR, and the margin of the lesion were highly specific in differentiation, both L.N status and number were found that they were highly specific in differentiation (p <0.001), while size of the lesion, T1WI signal, ADC values were found that they were non-specific in differentiation between the molecular subtypes of breast cancer. Conclusion: Breast MRI may help in assessing different molecular subtypes of breast cancer. |
| first_indexed | 2024-12-10T10:42:36Z |
| format | Article |
| id | doaj.art-fd0d31505b3b4b658f7ea914d9e6ef9f |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-12-10T10:42:36Z |
| publishDate | 2022-01-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-fd0d31505b3b4b658f7ea914d9e6ef9f2022-12-22T01:52:15ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022022-01-01513447https://dx.doi.org/10.21608/svuijm.2021.99249.1226Utility of MRI in diagnosis of molecular subtypes of breast cancerEbtsam Ahmed Mohammed*0Mohamed Tharwat Mahmoud Solyman1 Nagham Nabil Omar2Nahla Mohamed Ali Hasan3Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.Department of Radio-Diagnosis, Faculty of Medicine, Assiut University, Assiut, Egypt.Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.Background: Breast cancer is a collection of diseases defined by distinct pathological (e.g., ductal, lobular, mucinous) and molecular characteristics (e.g., ER and PR, HER2 amplification, and more recently transcriptome-based classifications such as luminal and basal cancers). Molecular subtyping is beneficial for the diagnosis and individualized treatment of breast cancer.MRI is a supplemental technique to mammography and ultrasonography for the evaluation of breast lesions and to predict molecular subtypes of breast cancer. Studies have highlighted the value of DCE-MRI in reflecting the anatomic and functional properties of tumors and facilitating treatment. Objectives: The aim of this work was to assess the utility of MRI as an accurate method for detection of molecular subtypes of breast cancer. Patients and Methods: a retrospective clinical study of 2-years enrollment duration. The study was conducted at Radiology Department, Assuit University Hospitals on 50 lesions, patient age ranging from 23 to 66 years old with mean age was (46.9 ± SD) years. MR imaging studies were performed using a 1.5 T Magnetom Vision scanner with dedicated bilateral phased-array breast coil (Siemens, Erlangen, Germany). MRI sequences were 1. Axial T1WI. 2. Axial T2WI. 3. Axial STIR. 4. Axial DWI and ADC. 5. DCE-MRI. Results: The study included 50 lesions; 21 lesions were Luminal A, 15 lesions were Luminal B, 10 lesions were HER2+, and 4 lesions were TN. Histopathology 39 lesions were IDC-NOS, 1 lesion was IDC (medullary type), 7 lesions were mixed pathology IDC + DCIS, and 3 lesions were ILC. As regard the correlation between the histopathological type and grade, both were specific in differentiation between the molecular subtypes. According to the MRI findings it was found that T2 Intratumoral signal intensity, STIR, and the margin of the lesion were highly specific in differentiation, both L.N status and number were found that they were highly specific in differentiation (p <0.001), while size of the lesion, T1WI signal, ADC values were found that they were non-specific in differentiation between the molecular subtypes of breast cancer. Conclusion: Breast MRI may help in assessing different molecular subtypes of breast cancer.https://svuijm.journals.ekb.eg/article_199523.htmlmolecular subtype; luminal a; luminal b; her2+; triple-negative; mri; adc; dce-mri |
| spellingShingle | Ebtsam Ahmed Mohammed* Mohamed Tharwat Mahmoud Solyman Nagham Nabil Omar Nahla Mohamed Ali Hasan Utility of MRI in diagnosis of molecular subtypes of breast cancer SVU - International Journal of Medical Sciences molecular subtype; luminal a; luminal b; her2+; triple-negative; mri; adc; dce-mri |
| title | Utility of MRI in diagnosis of molecular subtypes of breast cancer |
| title_full | Utility of MRI in diagnosis of molecular subtypes of breast cancer |
| title_fullStr | Utility of MRI in diagnosis of molecular subtypes of breast cancer |
| title_full_unstemmed | Utility of MRI in diagnosis of molecular subtypes of breast cancer |
| title_short | Utility of MRI in diagnosis of molecular subtypes of breast cancer |
| title_sort | utility of mri in diagnosis of molecular subtypes of breast cancer |
| topic | molecular subtype; luminal a; luminal b; her2+; triple-negative; mri; adc; dce-mri |
| url | https://svuijm.journals.ekb.eg/article_199523.html |
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