Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial
Background/Aims The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26)...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2019-03-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2018-0084.pdf |
| _version_ | 1818996724510752768 |
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| author | Manoj Kumar Sharma Sumeet Kainth Sachin Kumar Ankit Bhardwaj Hemant Kumar Agarwal Rakhi Maiwall Kapil Dev Jamwal Saggere Muralikrishna Shasthry Ankur Jindal Ashok Choudhary Lovkesh Anand Rajender Mal Dhamija Guresh Kumar Barjesh Chander Sharma Shiv Kumar Sarin |
| author_facet | Manoj Kumar Sharma Sumeet Kainth Sachin Kumar Ankit Bhardwaj Hemant Kumar Agarwal Rakhi Maiwall Kapil Dev Jamwal Saggere Muralikrishna Shasthry Ankur Jindal Ashok Choudhary Lovkesh Anand Rajender Mal Dhamija Guresh Kumar Barjesh Chander Sharma Shiv Kumar Sarin |
| author_sort | Manoj Kumar Sharma |
| collection | DOAJ |
| description | Background/Aims The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture. |
| first_indexed | 2024-12-20T21:34:17Z |
| format | Article |
| id | doaj.art-fd0ecd234e2f416eb2dd27548be670c0 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-20T21:34:17Z |
| publishDate | 2019-03-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-fd0ecd234e2f416eb2dd27548be670c02022-12-21T19:25:59ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2019-03-0125219920910.3350/cmh.2018.00841453Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trialManoj Kumar Sharma0Sumeet Kainth1Sachin Kumar2Ankit Bhardwaj3Hemant Kumar Agarwal4Rakhi Maiwall5Kapil Dev Jamwal6Saggere Muralikrishna Shasthry7Ankur Jindal8Ashok Choudhary9Lovkesh Anand10Rajender Mal Dhamija11Guresh Kumar12Barjesh Chander Sharma13Shiv Kumar Sarin14 Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Pulmonary Medicine, Institute of Liver and Biliary Sciences, New Delhi, India Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India Department of Pulmonary Medicine, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Neurology, Institute of Liver and Biliary Sciences, New Delhi, India Department of Biostatistics, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, IndiaBackground/Aims The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.http://e-cmh.org/upload/pdf/cmh-2018-0084.pdfCirrhosisSleepZolpidemInsomnia |
| spellingShingle | Manoj Kumar Sharma Sumeet Kainth Sachin Kumar Ankit Bhardwaj Hemant Kumar Agarwal Rakhi Maiwall Kapil Dev Jamwal Saggere Muralikrishna Shasthry Ankur Jindal Ashok Choudhary Lovkesh Anand Rajender Mal Dhamija Guresh Kumar Barjesh Chander Sharma Shiv Kumar Sarin Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial Clinical and Molecular Hepatology Cirrhosis Sleep Zolpidem Insomnia |
| title | Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial |
| title_full | Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial |
| title_fullStr | Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial |
| title_full_unstemmed | Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial |
| title_short | Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial |
| title_sort | effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances a randomized placebo controlled trial |
| topic | Cirrhosis Sleep Zolpidem Insomnia |
| url | http://e-cmh.org/upload/pdf/cmh-2018-0084.pdf |
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