Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review
Diabetes mellitus (DM) is a metabolic syndrome that can be considered a growing health problem in the world. High blood glucose levels are one of the most notable clinical signs. Currently, new therapeutic alternatives have been tackled from clinicians’ and scientists’ points of view. Natural produc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/1/85 |
| _version_ | 1797437882829373440 |
|---|---|
| author | Ingrid Andrea Rodríguez Mairim Serafini Izabel Almeida Alves Karen Luise Lang Fátima Regina Mena Barreto Silva Diana Marcela Aragón |
| author_facet | Ingrid Andrea Rodríguez Mairim Serafini Izabel Almeida Alves Karen Luise Lang Fátima Regina Mena Barreto Silva Diana Marcela Aragón |
| author_sort | Ingrid Andrea Rodríguez |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic syndrome that can be considered a growing health problem in the world. High blood glucose levels are one of the most notable clinical signs. Currently, new therapeutic alternatives have been tackled from clinicians’ and scientists’ points of view. Natural products are considered a promising source, due to the huge diversity of metabolites with pharmaceutical applications. Therefore, this review aimed to uncover the latest advances in this field as a potential alternative to the current therapeutic strategies for the treatment of DM. This purpose is achieved after a patent review, using the Espacenet database of the European Patent Office (EPO) (2016–2022). Final screening allowed us to investigate 19 patents, their components, and several technology strategies in DM. Plants, seaweeds, fungi, and minerals were used as raw materials in the patents. Additionally, metabolites such as tannins, organic acids, polyphenols, terpenes, and flavonoids were found to be related to the potential activity in DM. Moreover, the cellular transportation of active ingredients and solid forms with special drug delivery profiles is also considered a pharmaceutical technology strategy that can improve their safety and efficacy. From this perspective, natural products can be a promissory source to obtain new drugs for DM therapy. |
| first_indexed | 2024-03-09T11:29:04Z |
| format | Article |
| id | doaj.art-fd13df4555664ad3ba7f80926d8773e6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:29:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-fd13df4555664ad3ba7f80926d8773e62023-11-30T23:57:26ZengMDPI AGPharmaceutics1999-49232022-12-011518510.3390/pharmaceutics15010085Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent ReviewIngrid Andrea Rodríguez0Mairim Serafini1Izabel Almeida Alves2Karen Luise Lang3Fátima Regina Mena Barreto Silva4Diana Marcela Aragón5Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 110321, D.C., ColombiaDepartamento de Farmácia, Universidade Federal de Sergipe, Sao Cristovao 49100-000, SE, BrazilDepartment of Medicines, Faculty of Pharmacy, Universidade Federal da Bahia, Salvador 40170-115, BA, BrazilDepartamento de Farmácia, Campus Governador Valadares, Universidade Federal de Juiz de Fora, Governador Valadares, Juiz de Fora 36038-330, MG, BrazilDepartamento de Bioquímica—Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Rua João Pio Duarte Silva, Florianópolis 88037-000, SC, BrazilDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá 110321, D.C., ColombiaDiabetes mellitus (DM) is a metabolic syndrome that can be considered a growing health problem in the world. High blood glucose levels are one of the most notable clinical signs. Currently, new therapeutic alternatives have been tackled from clinicians’ and scientists’ points of view. Natural products are considered a promising source, due to the huge diversity of metabolites with pharmaceutical applications. Therefore, this review aimed to uncover the latest advances in this field as a potential alternative to the current therapeutic strategies for the treatment of DM. This purpose is achieved after a patent review, using the Espacenet database of the European Patent Office (EPO) (2016–2022). Final screening allowed us to investigate 19 patents, their components, and several technology strategies in DM. Plants, seaweeds, fungi, and minerals were used as raw materials in the patents. Additionally, metabolites such as tannins, organic acids, polyphenols, terpenes, and flavonoids were found to be related to the potential activity in DM. Moreover, the cellular transportation of active ingredients and solid forms with special drug delivery profiles is also considered a pharmaceutical technology strategy that can improve their safety and efficacy. From this perspective, natural products can be a promissory source to obtain new drugs for DM therapy.https://www.mdpi.com/1999-4923/15/1/85diabetes mellitusnatural productsflavonoidspolyphenolspatent |
| spellingShingle | Ingrid Andrea Rodríguez Mairim Serafini Izabel Almeida Alves Karen Luise Lang Fátima Regina Mena Barreto Silva Diana Marcela Aragón Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review Pharmaceutics diabetes mellitus natural products flavonoids polyphenols patent |
| title | Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review |
| title_full | Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review |
| title_fullStr | Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review |
| title_full_unstemmed | Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review |
| title_short | Natural Products as Outstanding Alternatives in Diabetes Mellitus: A Patent Review |
| title_sort | natural products as outstanding alternatives in diabetes mellitus a patent review |
| topic | diabetes mellitus natural products flavonoids polyphenols patent |
| url | https://www.mdpi.com/1999-4923/15/1/85 |
| work_keys_str_mv | AT ingridandrearodriguez naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview AT mairimserafini naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview AT izabelalmeidaalves naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview AT karenluiselang naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview AT fatimareginamenabarretosilva naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview AT dianamarcelaaragon naturalproductsasoutstandingalternativesindiabetesmellitusapatentreview |