The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation
Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal im...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/10/808 |
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| author | Yuichi Akama Naoko Satoh-Takayama Eiji Kawamoto Atsushi Ito Arong Gaowa Eun Jeong Park Hiroshi Imai Motomu Shimaoka |
| author_facet | Yuichi Akama Naoko Satoh-Takayama Eiji Kawamoto Atsushi Ito Arong Gaowa Eun Jeong Park Hiroshi Imai Motomu Shimaoka |
| author_sort | Yuichi Akama |
| collection | DOAJ |
| description | Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal immune cells regulating lung inflammation, group two innate lymphoid cells (ILC2s) have recently been identified as a new player regulating immune homeostasis. ILC2 is one of the three major ILC subsets (ILC1s, ILC2s, and ILC3s) comprised of newly identified innate immune cells. These cells are characterized by their ability to rapidly produce type 2 cytokines. ILC2s are predominant resident ILCs and, thereby, have the ability to respond to signals from damaged tissues. ILC2s regulate the immune response, and ILC2-derived type 2 cytokines may exert protective roles against sepsis-induced lung injury. This focused review not only provides readers with new insights into the signaling mechanisms by which ILC2s modulate sepsis-induced lung inflammation, but also proposes ILC2 as a novel therapeutic target for sepsis-induced ALI. |
| first_indexed | 2024-03-10T15:43:02Z |
| format | Article |
| id | doaj.art-fd13fb53861d4586b90fdf0a833201e6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T15:43:02Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-fd13fb53861d4586b90fdf0a833201e62023-11-20T16:43:59ZengMDPI AGDiagnostics2075-44182020-10-01101080810.3390/diagnostics10100808The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung InflammationYuichi Akama0Naoko Satoh-Takayama1Eiji Kawamoto2Atsushi Ito3Arong Gaowa4Eun Jeong Park5Hiroshi Imai6Motomu Shimaoka7Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanLaboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, JapanDepartment of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanDepartment of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanDepartment of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanDepartment of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanDepartment of Emergency and Disaster Medicine, Faculty, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanDepartment of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, JapanSeptic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal immune cells regulating lung inflammation, group two innate lymphoid cells (ILC2s) have recently been identified as a new player regulating immune homeostasis. ILC2 is one of the three major ILC subsets (ILC1s, ILC2s, and ILC3s) comprised of newly identified innate immune cells. These cells are characterized by their ability to rapidly produce type 2 cytokines. ILC2s are predominant resident ILCs and, thereby, have the ability to respond to signals from damaged tissues. ILC2s regulate the immune response, and ILC2-derived type 2 cytokines may exert protective roles against sepsis-induced lung injury. This focused review not only provides readers with new insights into the signaling mechanisms by which ILC2s modulate sepsis-induced lung inflammation, but also proposes ILC2 as a novel therapeutic target for sepsis-induced ALI.https://www.mdpi.com/2075-4418/10/10/808PD-1group 2 innate lymphoid cellssepsisacute lung injuryIL-13IL-33 |
| spellingShingle | Yuichi Akama Naoko Satoh-Takayama Eiji Kawamoto Atsushi Ito Arong Gaowa Eun Jeong Park Hiroshi Imai Motomu Shimaoka The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation Diagnostics PD-1 group 2 innate lymphoid cells sepsis acute lung injury IL-13 IL-33 |
| title | The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation |
| title_full | The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation |
| title_fullStr | The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation |
| title_full_unstemmed | The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation |
| title_short | The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation |
| title_sort | role of innate lymphoid cells in the regulation of immune homeostasis in sepsis mediated lung inflammation |
| topic | PD-1 group 2 innate lymphoid cells sepsis acute lung injury IL-13 IL-33 |
| url | https://www.mdpi.com/2075-4418/10/10/808 |
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