SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION
The possibility of creating a self-expanding stent, consisting of a combination of the saline and the basic form of chitosan have been discussed. The 2 % chitosan solution in 4 % citric acid have been prepared. The spinning solution have been coated onto an inert substrate in a volume of 0.2-0.25 ml...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Volgograd State University
2016-04-01
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| Series: | Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki |
| Subjects: | |
| Online Access: | http://ns.jvolsu.com/index.php/en/component/attachments/download/379 |
| _version_ | 1811254155697717248 |
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| author | Kovalenko A.V. Shinkarev R.V. Borozdina N.A. |
| author_facet | Kovalenko A.V. Shinkarev R.V. Borozdina N.A. |
| author_sort | Kovalenko A.V. |
| collection | DOAJ |
| description | The possibility of creating a self-expanding stent, consisting of a combination of the saline and the basic form of chitosan have been discussed. The 2 % chitosan solution in 4 % citric acid have been prepared. The spinning solution have been coated onto an inert substrate in a volume of 0.2-0.25 ml/cm2. Chitosan film (saline form) have been obtained by evaporation of the solvent at room temperature under static conditions. Chitosan film thickness have been measured with a micrometer. Samples of chitosan stents have been formed by winding a chitosan film on the plastic tube. The optimal concentration of NaOH and the dwell time for transfer of chitosan in the form of a saline form to basic form have been defined. The stents photos with a hundredfold magnification and AFM-images of the samples surface have been obtained. The estimate of the stent elongation at break (e) (31-46 %) have been evaluated and have been found that the data on this indicator stents are higher than those obtained from the films form with acetic acid (17 %). These results open up the possibility to create biocompatible biliary stents with their subsequent modification of the active drug substance, which gives hope for improvement of treatment results in patients with obstruction of extrahepatic bile ducts. |
| first_indexed | 2024-04-12T17:01:59Z |
| format | Article |
| id | doaj.art-fd14d44a2d3a46889967112c59ae0ae7 |
| institution | Directory Open Access Journal |
| issn | 2306-4153 2409-2762 |
| language | Russian |
| last_indexed | 2024-04-12T17:01:59Z |
| publishDate | 2016-04-01 |
| publisher | Volgograd State University |
| record_format | Article |
| series | Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki |
| spelling | doaj.art-fd14d44a2d3a46889967112c59ae0ae72022-12-22T03:24:03ZrusVolgograd State UniversityVestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki2306-41532409-27622016-04-01151263210.15688/jvolsu11.2016.1.3SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATIONKovalenko A.V.0Shinkarev R.V.1Borozdina N.A.2Volgograd State UniversityVolgograd State UniversityVolgograd State UniversityThe possibility of creating a self-expanding stent, consisting of a combination of the saline and the basic form of chitosan have been discussed. The 2 % chitosan solution in 4 % citric acid have been prepared. The spinning solution have been coated onto an inert substrate in a volume of 0.2-0.25 ml/cm2. Chitosan film (saline form) have been obtained by evaporation of the solvent at room temperature under static conditions. Chitosan film thickness have been measured with a micrometer. Samples of chitosan stents have been formed by winding a chitosan film on the plastic tube. The optimal concentration of NaOH and the dwell time for transfer of chitosan in the form of a saline form to basic form have been defined. The stents photos with a hundredfold magnification and AFM-images of the samples surface have been obtained. The estimate of the stent elongation at break (e) (31-46 %) have been evaluated and have been found that the data on this indicator stents are higher than those obtained from the films form with acetic acid (17 %). These results open up the possibility to create biocompatible biliary stents with their subsequent modification of the active drug substance, which gives hope for improvement of treatment results in patients with obstruction of extrahepatic bile ducts.http://ns.jvolsu.com/index.php/en/component/attachments/download/379 сhitosan in saline formchitosan in basic formfilmstentcitric acidalkalibiocompatibilityelongation at breakbiodegradation |
| spellingShingle | Kovalenko A.V. Shinkarev R.V. Borozdina N.A. SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 11. Estestvennye Nauki сhitosan in saline form chitosan in basic form film stent citric acid alkali biocompatibility elongation at break biodegradation |
| title | SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION |
| title_full | SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION |
| title_fullStr | SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION |
| title_full_unstemmed | SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION |
| title_short | SELF-EXPANDABLE CHITOSAN STENT – A TECHNOLOGY OF FABRICATION |
| title_sort | self expandable chitosan stent a technology of fabrication |
| topic | сhitosan in saline form chitosan in basic form film stent citric acid alkali biocompatibility elongation at break biodegradation |
| url | http://ns.jvolsu.com/index.php/en/component/attachments/download/379 |
| work_keys_str_mv | AT kovalenkoav selfexpandablechitosanstentatechnologyoffabrication AT shinkarevrv selfexpandablechitosanstentatechnologyoffabrication AT borozdinana selfexpandablechitosanstentatechnologyoffabrication |