Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model

Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (BDNF). In HD, diminished BDNF transport leads to reduced BDNF...

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Bibliographic Details
Main Authors: Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Huntingtin
Pridopidine
Sigma-1 receptor
Neuroprotection
BDNF/TrkB trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002492

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http://www.sciencedirect.com/science/article/pii/S0969996122002492

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