Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition

Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition

Colorectal cancer (CRC) is the second deadliest cancer in the world. Besides APC and p53 alterations, the PI3K/AKT/MTOR and MAPK pathway are most commonly mutated in CRC. So far, no treatment options targeting these pathways are available in routine clinics for CRC patients. We systematically analyz...

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Bibliographic Details
Main Authors: Velina S. Atanasova, Angelika Riedl, Marcus Strobl, Julia Flandorfer, Daniela Unterleuthner, Claudia Weindorfer, Patrick Neuhold, Simone Stang, Markus Hengstschläger, Michael Bergmann, Helmut Dolznig
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
3D culture
targeted therapy
colorectal cancer
organoids
precision medicine
Online Access:https://www.mdpi.com/1422-0067/24/2/1668

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