GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation

GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation

Direct (intracisternal) injection of aluminum complexes into rabbit brain results in a number of similarities with the neuropathological and biochemical changes observed in Alzheimer's disease and provides the opportunity to assess early events in neurodegeneration. This mode of administration...

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Bibliographic Details
Main Authors: Othman Ghribi, Mary M. Herman, Michael S. Forbes, David A. DeWitt, John Savory
Format: Article
Language:English
Published: Elsevier 2001-10-01
Series:Neurobiology of Disease
Subjects:
cytochrome c
Bax
Bcl-2
Bcl-XL
caspase-3
GDNF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904292

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