Lady Windermere syndrome
Non-tuberculosis Mycobacterium spp (NTM) pulmonary disease is increasing in incidence and is a common cause of undiagnosed lung disease in older patients. NTM pulmonary disease occurring in patients without preexisting lung disease was only recently described by Prince in 1988. In 1992, Reich and Jo...
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| Format: | Article |
| Language: | English |
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Southwest Respiratory and Critical Care Chronicles
2017-07-01
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| Series: | Southwest Respiratory and Critical Care Chronicles |
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| Online Access: | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/402 |
| _version_ | 1818968771399778304 |
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| author | Ann Marie Kumfer Hawa Edriss |
| author_facet | Ann Marie Kumfer Hawa Edriss |
| author_sort | Ann Marie Kumfer |
| collection | DOAJ |
| description | Non-tuberculosis Mycobacterium spp (NTM) pulmonary disease is increasing in incidence
and is a common cause of undiagnosed lung disease in older patients. NTM pulmonary
disease occurring in patients without preexisting lung disease was only recently described by
Prince in 1988. In 1992, Reich and Johnson presented a case series of six women describing
a predilection of Mycobacterium spp pulmonary disease for the middle lobe, and its homolog,
the lingula, in elderly women without preexisting pulmonary disease. Later high resolution
computed tomography studies (HRCT) showed that the characteristic image findings in these
cases were nodules and bronchiectasis most commonly occurring in the middle lobe and
lingula. This subtype of disease is now usually referred to as nodular bronchiectasis, and
some researchers have doubted whether there really is a predilection for the middle lobe.
Although Reich and Johnson hypothesized that cough suppression in “polite” women was the
mechanism of disease, there are no large studies which support this idea. Mutations in the
cystic fibrosis transmembrane receptor, unique skeletal phenotypes, and impaired function of
the modulators of granuloma formation are the most common characteristics found in patients
with nodular bronchiectasis. These patients usually respond well to clarithromycin-based multidrug
regimens, but surgery is sometimes required to resect the infected regions of the lung. |
| first_indexed | 2024-12-20T14:09:59Z |
| format | Article |
| id | doaj.art-fd19a3cc07884da9adefd6c43e70661e |
| institution | Directory Open Access Journal |
| issn | 2325-9205 |
| language | English |
| last_indexed | 2024-12-20T14:09:59Z |
| publishDate | 2017-07-01 |
| publisher | Southwest Respiratory and Critical Care Chronicles |
| record_format | Article |
| series | Southwest Respiratory and Critical Care Chronicles |
| spelling | doaj.art-fd19a3cc07884da9adefd6c43e70661e2022-12-21T19:38:11ZengSouthwest Respiratory and Critical Care ChroniclesSouthwest Respiratory and Critical Care Chronicles2325-92052017-07-01520223210.12746/swrccc.v5i20.402331Lady Windermere syndromeAnn Marie Kumfer0Hawa Edriss1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TXDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TXNon-tuberculosis Mycobacterium spp (NTM) pulmonary disease is increasing in incidence and is a common cause of undiagnosed lung disease in older patients. NTM pulmonary disease occurring in patients without preexisting lung disease was only recently described by Prince in 1988. In 1992, Reich and Johnson presented a case series of six women describing a predilection of Mycobacterium spp pulmonary disease for the middle lobe, and its homolog, the lingula, in elderly women without preexisting pulmonary disease. Later high resolution computed tomography studies (HRCT) showed that the characteristic image findings in these cases were nodules and bronchiectasis most commonly occurring in the middle lobe and lingula. This subtype of disease is now usually referred to as nodular bronchiectasis, and some researchers have doubted whether there really is a predilection for the middle lobe. Although Reich and Johnson hypothesized that cough suppression in “polite” women was the mechanism of disease, there are no large studies which support this idea. Mutations in the cystic fibrosis transmembrane receptor, unique skeletal phenotypes, and impaired function of the modulators of granuloma formation are the most common characteristics found in patients with nodular bronchiectasis. These patients usually respond well to clarithromycin-based multidrug regimens, but surgery is sometimes required to resect the infected regions of the lung.http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/402Lady Windermere Syndromenodular bronchiectasisM. aviumnon-tuberculous Mycobacterial spp (NTM) |
| spellingShingle | Ann Marie Kumfer Hawa Edriss Lady Windermere syndrome Southwest Respiratory and Critical Care Chronicles Lady Windermere Syndrome nodular bronchiectasis M. avium non-tuberculous Mycobacterial spp (NTM) |
| title | Lady Windermere syndrome |
| title_full | Lady Windermere syndrome |
| title_fullStr | Lady Windermere syndrome |
| title_full_unstemmed | Lady Windermere syndrome |
| title_short | Lady Windermere syndrome |
| title_sort | lady windermere syndrome |
| topic | Lady Windermere Syndrome nodular bronchiectasis M. avium non-tuberculous Mycobacterial spp (NTM) |
| url | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/402 |
| work_keys_str_mv | AT annmariekumfer ladywindermeresyndrome AT hawaedriss ladywindermeresyndrome |