Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study
Abstract Background Surgical treatment for metastatic pathological femur fractures is associated with high mortality. Correct estimation of prognosis helps in determining the palliative value of surgical treatment and informs surgical decision. This study evaluates the risk factors for mortality in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01632-7 |
| _version_ | 1811305182145806336 |
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| author | David Shaoen Sim Suraya Zainul-Abidin Eileen Yilin Sim Chu Sheng Seng Shern-En Evan Tan Mann Hong Tan Tet Sen Howe Joyce Suang Bee Koh |
| author_facet | David Shaoen Sim Suraya Zainul-Abidin Eileen Yilin Sim Chu Sheng Seng Shern-En Evan Tan Mann Hong Tan Tet Sen Howe Joyce Suang Bee Koh |
| author_sort | David Shaoen Sim |
| collection | DOAJ |
| description | Abstract Background Surgical treatment for metastatic pathological femur fractures is associated with high mortality. Correct estimation of prognosis helps in determining the palliative value of surgical treatment and informs surgical decision. This study evaluates the risk factors for mortality in these patients who were surgically treated. Methods This is a retrospective study of 112 patients with surgical treatment of metastatic pathological femur fractures. Risk factors evaluated included age, ASA status, Charlson comorbidity index, preoperative serum albumin and haemoglobin, primary tumour site, presence of visceral metastases, presence of spinal metastases, time from diagnosis of cancer to occurrence of pathological fracture, type of surgical procedure performed, lesion and whether treatment was received for an actual or impending fracture. A Cox regression model was used to determine if these factors were independent significant factors for survival. Results Mortality at 2 years after surgical treatment of metastatic femoral fractures was 86%. Cox regression analysis of risk factors revealed that preoperative serum albumin and type primary tumour were independent risk factors for mortality. Presence of visceral metastases was strongly correlated to serum albumin levels. Conclusion Preoperative serum albumin level and primary tumour site are independent risk factors of survival in patients treated for pathological femur fractures. Serum albumin level may be used as a prognostic tool to guide treatment in this cohort of patients with high mortality rates. |
| first_indexed | 2024-04-13T08:21:56Z |
| format | Article |
| id | doaj.art-fd1a16759c8f42ec8718319422c396a0 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T08:21:56Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-fd1a16759c8f42ec8718319422c396a02022-12-22T02:54:38ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-04-011511710.1186/s13018-020-01632-7Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective studyDavid Shaoen Sim0Suraya Zainul-Abidin1Eileen Yilin Sim2Chu Sheng Seng3Shern-En Evan Tan4Mann Hong Tan5Tet Sen Howe6Joyce Suang Bee Koh7Singapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalAbstract Background Surgical treatment for metastatic pathological femur fractures is associated with high mortality. Correct estimation of prognosis helps in determining the palliative value of surgical treatment and informs surgical decision. This study evaluates the risk factors for mortality in these patients who were surgically treated. Methods This is a retrospective study of 112 patients with surgical treatment of metastatic pathological femur fractures. Risk factors evaluated included age, ASA status, Charlson comorbidity index, preoperative serum albumin and haemoglobin, primary tumour site, presence of visceral metastases, presence of spinal metastases, time from diagnosis of cancer to occurrence of pathological fracture, type of surgical procedure performed, lesion and whether treatment was received for an actual or impending fracture. A Cox regression model was used to determine if these factors were independent significant factors for survival. Results Mortality at 2 years after surgical treatment of metastatic femoral fractures was 86%. Cox regression analysis of risk factors revealed that preoperative serum albumin and type primary tumour were independent risk factors for mortality. Presence of visceral metastases was strongly correlated to serum albumin levels. Conclusion Preoperative serum albumin level and primary tumour site are independent risk factors of survival in patients treated for pathological femur fractures. Serum albumin level may be used as a prognostic tool to guide treatment in this cohort of patients with high mortality rates.http://link.springer.com/article/10.1186/s13018-020-01632-7AlbuminRisk factorSurvivalMetastatic femur fracture |
| spellingShingle | David Shaoen Sim Suraya Zainul-Abidin Eileen Yilin Sim Chu Sheng Seng Shern-En Evan Tan Mann Hong Tan Tet Sen Howe Joyce Suang Bee Koh Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study Journal of Orthopaedic Surgery and Research Albumin Risk factor Survival Metastatic femur fracture |
| title | Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study |
| title_full | Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study |
| title_fullStr | Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study |
| title_full_unstemmed | Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study |
| title_short | Serum albumin level predicts survival after surgical treatment of metastatic femur fractures: a retrospective study |
| title_sort | serum albumin level predicts survival after surgical treatment of metastatic femur fractures a retrospective study |
| topic | Albumin Risk factor Survival Metastatic femur fracture |
| url | http://link.springer.com/article/10.1186/s13018-020-01632-7 |
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