Kronos scRT: a uniform framework for single-cell replication timing analysis

A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.

Bibliographic Details
Main Authors: Stefano Gnan, Joseph M. Josephides, Xia Wu, Manuela Spagnuolo, Dalila Saulebekova, Mylène Bohec, Marie Dumont, Laura G. Baudrin, Daniele Fachinetti, Sylvain Baulande, Chun-Long Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30043-x
Description
Summary:A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.
ISSN:2041-1723