Kronos scRT: a uniform framework for single-cell replication timing analysis
A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30043-x |
| _version_ | 1811338842020511744 |
|---|---|
| author | Stefano Gnan Joseph M. Josephides Xia Wu Manuela Spagnuolo Dalila Saulebekova Mylène Bohec Marie Dumont Laura G. Baudrin Daniele Fachinetti Sylvain Baulande Chun-Long Chen |
| author_facet | Stefano Gnan Joseph M. Josephides Xia Wu Manuela Spagnuolo Dalila Saulebekova Mylène Bohec Marie Dumont Laura G. Baudrin Daniele Fachinetti Sylvain Baulande Chun-Long Chen |
| author_sort | Stefano Gnan |
| collection | DOAJ |
| description | A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths. |
| first_indexed | 2024-04-13T18:16:36Z |
| format | Article |
| id | doaj.art-fd1aed25b9a042d2a333d9c51e20f10b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T18:16:36Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fd1aed25b9a042d2a333d9c51e20f10b2022-12-22T02:35:39ZengNature PortfolioNature Communications2041-17232022-04-0113111510.1038/s41467-022-30043-xKronos scRT: a uniform framework for single-cell replication timing analysisStefano Gnan0Joseph M. Josephides1Xia Wu2Manuela Spagnuolo3Dalila Saulebekova4Mylène Bohec5Marie Dumont6Laura G. Baudrin7Daniele Fachinetti8Sylvain Baulande9Chun-Long Chen10Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéInstitut Curie, Genomics of Excellence (ICGex) Platform, PSL Research UniversityInstitut Curie, PSL Research University, CNRS UMR144, Cell Biology and CancerInstitut Curie, Genomics of Excellence (ICGex) Platform, PSL Research UniversityInstitut Curie, PSL Research University, CNRS UMR144, Cell Biology and CancerInstitut Curie, Genomics of Excellence (ICGex) Platform, PSL Research UniversityInstitut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne UniversitéA scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.https://doi.org/10.1038/s41467-022-30043-x |
| spellingShingle | Stefano Gnan Joseph M. Josephides Xia Wu Manuela Spagnuolo Dalila Saulebekova Mylène Bohec Marie Dumont Laura G. Baudrin Daniele Fachinetti Sylvain Baulande Chun-Long Chen Kronos scRT: a uniform framework for single-cell replication timing analysis Nature Communications |
| title | Kronos scRT: a uniform framework for single-cell replication timing analysis |
| title_full | Kronos scRT: a uniform framework for single-cell replication timing analysis |
| title_fullStr | Kronos scRT: a uniform framework for single-cell replication timing analysis |
| title_full_unstemmed | Kronos scRT: a uniform framework for single-cell replication timing analysis |
| title_short | Kronos scRT: a uniform framework for single-cell replication timing analysis |
| title_sort | kronos scrt a uniform framework for single cell replication timing analysis |
| url | https://doi.org/10.1038/s41467-022-30043-x |
| work_keys_str_mv | AT stefanognan kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT josephmjosephides kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT xiawu kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT manuelaspagnuolo kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT dalilasaulebekova kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT mylenebohec kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT mariedumont kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT lauragbaudrin kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT danielefachinetti kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT sylvainbaulande kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis AT chunlongchen kronosscrtauniformframeworkforsinglecellreplicationtiminganalysis |