The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke
Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients. Methods: We carried out a matched (age and gender) case-control study, in a sample of consecutive patients with...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Cerebral Circulation - Cognition and Behavior |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666245021000143 |
| _version_ | 1828077075349635072 |
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| author | Lara Caeiro Filipa Novais Carlota Saldanha Teresa Pinho e Melo Patrícia Canhão José M. Ferro |
| author_facet | Lara Caeiro Filipa Novais Carlota Saldanha Teresa Pinho e Melo Patrícia Canhão José M. Ferro |
| author_sort | Lara Caeiro |
| collection | DOAJ |
| description | Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients. Methods: We carried out a matched (age and gender) case-control study, in a sample of consecutive patients with an acute infarct or intracerebral haemorrhage (≤7 days). We assessed delirium using the DSM-5 criteria and the Delirium Rating Scale, and we measured plasma acetylcholinesterase and butyrylcholinesterase enzyme activity after the patient's admission in the stroke unit and before hospital discharge. Mantel-Haenszel's chi-square was used to test bivariate associations between cases (delirious patients) and controls (non-delirious patients). Results: At admission in the stroke unit, cases and controls did not present significant differences in plasma acetylcholinesterase or butyrylcholinesterase activity. At hospital discharge (18 cases and 21 controls) patients who have had delirium at admission had higher levels of butyrylcholinesterase activity. Butyrylcholinesterase activity may secondarily increase due to the inflammatory process associated with neuronal dysfunction in delirium patients. |
| first_indexed | 2024-04-11T02:25:25Z |
| format | Article |
| id | doaj.art-fd1b3cd2c8654b6381b702dbec2c304c |
| institution | Directory Open Access Journal |
| issn | 2666-2450 |
| language | English |
| last_indexed | 2024-04-11T02:25:25Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cerebral Circulation - Cognition and Behavior |
| spelling | doaj.art-fd1b3cd2c8654b6381b702dbec2c304c2023-01-02T22:56:21ZengElsevierCerebral Circulation - Cognition and Behavior2666-24502021-01-012100017The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute strokeLara Caeiro0Filipa Novais1Carlota Saldanha2Teresa Pinho e Melo3Patrícia Canhão4José M. Ferro5Institute of Molecular Medicine, Faculty of Medicine of the University of Lisbon, Portugal; Corresponding author:Serviço de Neurologia, Hospital de Santa Maria, 1649-035 Lisboa, Portugal.Psychiatry Service, Department of Neurosciences, Hospital de Santa Maria/CHLN, PortugalInstituto de Bioquímica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, PortugalNeurology Service, Department of Neurosciences, Hospital de Santa Maria/CHLN, PortugalNeurology Service, Department of Neurosciences, Hospital de Santa Maria/CHLN, and Institute of Molecular Medicine, University of Lisbon, PortugalNeurology Service, Department of Neurosciences, Hospital de Santa Maria/CHLN, and Institute of Molecular Medicine, University of Lisbon, PortugalAim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients. Methods: We carried out a matched (age and gender) case-control study, in a sample of consecutive patients with an acute infarct or intracerebral haemorrhage (≤7 days). We assessed delirium using the DSM-5 criteria and the Delirium Rating Scale, and we measured plasma acetylcholinesterase and butyrylcholinesterase enzyme activity after the patient's admission in the stroke unit and before hospital discharge. Mantel-Haenszel's chi-square was used to test bivariate associations between cases (delirious patients) and controls (non-delirious patients). Results: At admission in the stroke unit, cases and controls did not present significant differences in plasma acetylcholinesterase or butyrylcholinesterase activity. At hospital discharge (18 cases and 21 controls) patients who have had delirium at admission had higher levels of butyrylcholinesterase activity. Butyrylcholinesterase activity may secondarily increase due to the inflammatory process associated with neuronal dysfunction in delirium patients.http://www.sciencedirect.com/science/article/pii/S2666245021000143DeliriumStrokeAcuteAcetylcholinesteraseButyrylcholinesterase |
| spellingShingle | Lara Caeiro Filipa Novais Carlota Saldanha Teresa Pinho e Melo Patrícia Canhão José M. Ferro The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke Cerebral Circulation - Cognition and Behavior Delirium Stroke Acute Acetylcholinesterase Butyrylcholinesterase |
| title | The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| title_full | The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| title_fullStr | The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| title_full_unstemmed | The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| title_short | The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| title_sort | role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke |
| topic | Delirium Stroke Acute Acetylcholinesterase Butyrylcholinesterase |
| url | http://www.sciencedirect.com/science/article/pii/S2666245021000143 |
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