Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection
ObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients.MethodsHIV load, bacterial translocation and neutrophils’ expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.670966/full |
| _version_ | 1819009002295525376 |
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| author | Mercedes Márquez-Coello Mercedes Márquez-Coello Cristina Ruiz-Sánchez Cristina Ruiz-Sánchez Andrés Martín-Aspas Andrés Martín-Aspas Clotilde Fernández Gutiérrez Del Álamo Clotilde Fernández Gutiérrez Del Álamo Francisco Illanes-Álvarez Francisco Illanes-Álvarez Sara Cuesta-Sancho Sara Cuesta-Sancho José-Antonio Girón-González José-Antonio Girón-González |
| author_facet | Mercedes Márquez-Coello Mercedes Márquez-Coello Cristina Ruiz-Sánchez Cristina Ruiz-Sánchez Andrés Martín-Aspas Andrés Martín-Aspas Clotilde Fernández Gutiérrez Del Álamo Clotilde Fernández Gutiérrez Del Álamo Francisco Illanes-Álvarez Francisco Illanes-Álvarez Sara Cuesta-Sancho Sara Cuesta-Sancho José-Antonio Girón-González José-Antonio Girón-González |
| author_sort | Mercedes Márquez-Coello |
| collection | DOAJ |
| description | ObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients.MethodsHIV load, bacterial translocation and neutrophils’ expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study.ResultsCompared with the control group, group 1 patients showed increased bacterial translocation and their PMN had a significantly higher expression of T and B-cell immunomodulatory molecules, both at baseline and after 12 months of ART. Group 2 patients showed reduced bacterial translocation levels when compared with group 1 patients after 12 months of treatment. PMN expression of B-cell modulators was similar between group 2 patients and healthy controls, although the expression of T-cell modulators remained increased.ConclusionIn HIV-infected patients, the expression of B-cell stimulatory and T-cell suppressive molecules by neutrophils was increased at baseline and after a limited time of therapy. After a prolonged period of ART, only PMNs expression of T-cell immunosuppressive molecules remained elevated. |
| first_indexed | 2024-12-21T00:49:26Z |
| format | Article |
| id | doaj.art-fd1c22e00d2943a7a31e066e19ed0d01 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T00:49:26Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fd1c22e00d2943a7a31e066e19ed0d012022-12-21T19:21:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.670966670966Neutrophil Expression of T and B Immunomodulatory Molecules in HIV InfectionMercedes Márquez-Coello0Mercedes Márquez-Coello1Cristina Ruiz-Sánchez2Cristina Ruiz-Sánchez3Andrés Martín-Aspas4Andrés Martín-Aspas5Clotilde Fernández Gutiérrez Del Álamo6Clotilde Fernández Gutiérrez Del Álamo7Francisco Illanes-Álvarez8Francisco Illanes-Álvarez9Sara Cuesta-Sancho10Sara Cuesta-Sancho11José-Antonio Girón-González12José-Antonio Girón-González13Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainUnidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainUnidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainServicio de Microbiología, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainUnidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainUnidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainUnidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Universidad de Cádiz, Cádiz, SpainInstituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz (INiBICA), Cádiz, SpainObjectiveEvaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients.MethodsHIV load, bacterial translocation and neutrophils’ expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study.ResultsCompared with the control group, group 1 patients showed increased bacterial translocation and their PMN had a significantly higher expression of T and B-cell immunomodulatory molecules, both at baseline and after 12 months of ART. Group 2 patients showed reduced bacterial translocation levels when compared with group 1 patients after 12 months of treatment. PMN expression of B-cell modulators was similar between group 2 patients and healthy controls, although the expression of T-cell modulators remained increased.ConclusionIn HIV-infected patients, the expression of B-cell stimulatory and T-cell suppressive molecules by neutrophils was increased at baseline and after a limited time of therapy. After a prolonged period of ART, only PMNs expression of T-cell immunosuppressive molecules remained elevated.https://www.frontiersin.org/articles/10.3389/fimmu.2021.670966/fullHIVneutrophilsBAFFAPRILbacterial translocationinterleukins |
| spellingShingle | Mercedes Márquez-Coello Mercedes Márquez-Coello Cristina Ruiz-Sánchez Cristina Ruiz-Sánchez Andrés Martín-Aspas Andrés Martín-Aspas Clotilde Fernández Gutiérrez Del Álamo Clotilde Fernández Gutiérrez Del Álamo Francisco Illanes-Álvarez Francisco Illanes-Álvarez Sara Cuesta-Sancho Sara Cuesta-Sancho José-Antonio Girón-González José-Antonio Girón-González Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection Frontiers in Immunology HIV neutrophils BAFF APRIL bacterial translocation interleukins |
| title | Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection |
| title_full | Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection |
| title_fullStr | Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection |
| title_full_unstemmed | Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection |
| title_short | Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection |
| title_sort | neutrophil expression of t and b immunomodulatory molecules in hiv infection |
| topic | HIV neutrophils BAFF APRIL bacterial translocation interleukins |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.670966/full |
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