Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating
Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7705 |
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| author | Magdalena Antonowicz Janusz Szewczenko Joanna Jaworska Katarzyna Jelonek Kamil Joszko Bożena Gzik-Zroska Paweł M. Nuckowski Piotr Bryniarski Zbigniew Paszenda Damian S. Nakonieczny Karla Čech Barabaszová Janusz Kasperczyk |
| author_facet | Magdalena Antonowicz Janusz Szewczenko Joanna Jaworska Katarzyna Jelonek Kamil Joszko Bożena Gzik-Zroska Paweł M. Nuckowski Piotr Bryniarski Zbigniew Paszenda Damian S. Nakonieczny Karla Čech Barabaszová Janusz Kasperczyk |
| author_sort | Magdalena Antonowicz |
| collection | DOAJ |
| description | Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility. |
| first_indexed | 2024-03-10T09:36:51Z |
| format | Article |
| id | doaj.art-fd1d6272574f4e84870f779d2aad900f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:51Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fd1d6272574f4e84870f779d2aad900f2023-11-22T04:02:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214770510.3390/ijms22147705Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride CoatingMagdalena Antonowicz0Janusz Szewczenko1Joanna Jaworska2Katarzyna Jelonek3Kamil Joszko4Bożena Gzik-Zroska5Paweł M. Nuckowski6Piotr Bryniarski7Zbigniew Paszenda8Damian S. Nakonieczny9Karla Čech Barabaszová10Janusz Kasperczyk11Department of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, PolandCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, PolandDepartment of Biomechatronics, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandMaterials Research Laboratory, Faculty of Mechanical Engineering, Silesian University of Technology, 18A Konarskiego St., 44-100 Gliwice, PolandDepartment of Urology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 13-15 3 Maja St., 41-800 Zabrze, PolandDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandDepartment of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40 St., 41-800 Zabrze, PolandNanotechnology Centre, CEET, VŠB-Technical University of Ostrava, 17. Listopadu 15/2172, 708 00 Ostrava-Poruba, Czech RepublicCentre of Polymer and Carbon Materials of the Polish Academy of Sciences, 34 Marii Skłodowskiej-Curie St., 41-819 Zabrze, PolandDespite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.https://www.mdpi.com/1422-0067/22/14/7705ureteral stentPLGA with papaverine hydrochloride coatingsretention strengthbreak strengthdynamic frictional forceradiopacity |
| spellingShingle | Magdalena Antonowicz Janusz Szewczenko Joanna Jaworska Katarzyna Jelonek Kamil Joszko Bożena Gzik-Zroska Paweł M. Nuckowski Piotr Bryniarski Zbigniew Paszenda Damian S. Nakonieczny Karla Čech Barabaszová Janusz Kasperczyk Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating International Journal of Molecular Sciences ureteral stent PLGA with papaverine hydrochloride coatings retention strength break strength dynamic frictional force radiopacity |
| title | Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating |
| title_full | Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating |
| title_fullStr | Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating |
| title_full_unstemmed | Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating |
| title_short | Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating |
| title_sort | functional properties of polyurethane ureteral stents with plga and papaverine hydrochloride coating |
| topic | ureteral stent PLGA with papaverine hydrochloride coatings retention strength break strength dynamic frictional force radiopacity |
| url | https://www.mdpi.com/1422-0067/22/14/7705 |
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