Investigation on the Interaction between Cyclophosphamide and Lysozyme in the Presence of Three Different Kind of Cyclodextrins: Determination of the Binding Mechanism by Spectroscopic and Molecular Modeling Techniques

Investigation on the Interaction between Cyclophosphamide and Lysozyme in the Presence of Three Different Kind of Cyclodextrins: Determination of the Binding Mechanism by Spectroscopic and Molecular Modeling Techniques

The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in the presence of different cyclodextrins (CDs) were investigated by UV absorption, fluorescence spectroscopy, circular dichroism (CD), and molecular modeling techniques under imitated physiological conditions. The UV absorption res...

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Bibliographic Details
Main Authors: Jamshidkhan Chamani, Maryam Ghaderabad, Mohammad Reza Saberi, Malihe Pirouzi, Mahdieh Mansouri
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
lysozyme
cyclophosphamide
CDs (&#945
,&#946
,&#947
)
fluorescence quenching
circular dichroism
molecular modeling
Online Access:http://www.mdpi.com/1420-3049/18/1/789

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