Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Abstract Cell-free RNAs (cfRNAs) offer an opportunity to detect diseases from a transcriptomic perspective, however, existing techniques have fallen short in generating a comprehensive cell-free transcriptome profile. We develop a sensitive library preparation method that is robust down to 100 µl in...

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Bibliographic Details
Main Authors: Jun Wang, Jinyong Huang, Yunlong Hu, Qianwen Guo, Shasha Zhang, Jinglin Tian, Yanqin Niu, Ling Ji, Yuzhong Xu, Peijun Tang, Yaqin He, Yuna Wang, Shuya Zhang, Hao Yang, Kang Kang, Xinchun Chen, Xinying Li, Ming Yang, Deming Gou
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44461-y

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