Immune cell networking in solid tumors: focus on macrophages and neutrophils
The tumor microenvironment is composed of tumor cells, stromal cells and leukocytes, including innate and adaptive immune cells, and represents an ecological niche that regulates tumor development and progression. In general, inflammatory cells are considered to contribute to tumor progression throu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341390/full |
| _version_ | 1797311619352494080 |
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| author | Irene Di Ceglie Silvia Carnevale Anna Rigatelli Giovanna Grieco Giovanna Grieco Piera Molisso Piera Molisso Sebastien Jaillon Sebastien Jaillon |
| author_facet | Irene Di Ceglie Silvia Carnevale Anna Rigatelli Giovanna Grieco Giovanna Grieco Piera Molisso Piera Molisso Sebastien Jaillon Sebastien Jaillon |
| author_sort | Irene Di Ceglie |
| collection | DOAJ |
| description | The tumor microenvironment is composed of tumor cells, stromal cells and leukocytes, including innate and adaptive immune cells, and represents an ecological niche that regulates tumor development and progression. In general, inflammatory cells are considered to contribute to tumor progression through various mechanisms, including the formation of an immunosuppressive microenvironment. Macrophages and neutrophils are important components of the tumor microenvironment and can act as a double-edged sword, promoting or inhibiting the development of the tumor. Targeting of the immune system is emerging as an important therapeutic strategy for cancer patients. However, the efficacy of the various immunotherapies available is still limited. Given the crucial importance of the crosstalk between macrophages and neutrophils and other immune cells in the formation of the anti-tumor immune response, targeting these interactions may represent a promising therapeutic approach against cancer. Here we will review the current knowledge of the role played by macrophages and neutrophils in cancer, focusing on their interaction with other immune cells. |
| first_indexed | 2024-03-08T02:03:19Z |
| format | Article |
| id | doaj.art-fd21669f32f340c6b378696a6498d2c3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T02:03:19Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fd21669f32f340c6b378696a6498d2c32024-02-14T04:56:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13413901341390Immune cell networking in solid tumors: focus on macrophages and neutrophilsIrene Di Ceglie0Silvia Carnevale1Anna Rigatelli2Giovanna Grieco3Giovanna Grieco4Piera Molisso5Piera Molisso6Sebastien Jaillon7Sebastien Jaillon8IRCCS Humanitas Research Hospital, Milan, ItalyIRCCS Humanitas Research Hospital, Milan, ItalyIRCCS Humanitas Research Hospital, Milan, ItalyIRCCS Humanitas Research Hospital, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyIRCCS Humanitas Research Hospital, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyIRCCS Humanitas Research Hospital, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyThe tumor microenvironment is composed of tumor cells, stromal cells and leukocytes, including innate and adaptive immune cells, and represents an ecological niche that regulates tumor development and progression. In general, inflammatory cells are considered to contribute to tumor progression through various mechanisms, including the formation of an immunosuppressive microenvironment. Macrophages and neutrophils are important components of the tumor microenvironment and can act as a double-edged sword, promoting or inhibiting the development of the tumor. Targeting of the immune system is emerging as an important therapeutic strategy for cancer patients. However, the efficacy of the various immunotherapies available is still limited. Given the crucial importance of the crosstalk between macrophages and neutrophils and other immune cells in the formation of the anti-tumor immune response, targeting these interactions may represent a promising therapeutic approach against cancer. Here we will review the current knowledge of the role played by macrophages and neutrophils in cancer, focusing on their interaction with other immune cells.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341390/fulltumor microenvironmentanti-tumor immunitytumor-associated macrophagestumor-associated neutrophilsimmune cell network |
| spellingShingle | Irene Di Ceglie Silvia Carnevale Anna Rigatelli Giovanna Grieco Giovanna Grieco Piera Molisso Piera Molisso Sebastien Jaillon Sebastien Jaillon Immune cell networking in solid tumors: focus on macrophages and neutrophils Frontiers in Immunology tumor microenvironment anti-tumor immunity tumor-associated macrophages tumor-associated neutrophils immune cell network |
| title | Immune cell networking in solid tumors: focus on macrophages and neutrophils |
| title_full | Immune cell networking in solid tumors: focus on macrophages and neutrophils |
| title_fullStr | Immune cell networking in solid tumors: focus on macrophages and neutrophils |
| title_full_unstemmed | Immune cell networking in solid tumors: focus on macrophages and neutrophils |
| title_short | Immune cell networking in solid tumors: focus on macrophages and neutrophils |
| title_sort | immune cell networking in solid tumors focus on macrophages and neutrophils |
| topic | tumor microenvironment anti-tumor immunity tumor-associated macrophages tumor-associated neutrophils immune cell network |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341390/full |
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