Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction?
Dexmedetomidine has been widely used in the intensive care unit (ICU), with the primary aim to keep patients on an appropriate level of sedation. Both observational and randomized controlled trials have observed that the use of dexmedetomidine is associated with improved outcomes for mechanically ve...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-07-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2018.1542471 |
| _version_ | 1797684712552005632 |
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| author | Zhongheng Zhang |
| author_facet | Zhongheng Zhang |
| author_sort | Zhongheng Zhang |
| collection | DOAJ |
| description | Dexmedetomidine has been widely used in the intensive care unit (ICU), with the primary aim to keep patients on an appropriate level of sedation. Both observational and randomized controlled trials have observed that the use of dexmedetomidine is associated with improved outcomes for mechanically ventilated patients []. In ICU patients receiving prolonged mechanical ventilation, dexmedetomidine was not inferior to other sedatives in maintaining sedation level, but was associated with shortened MV duration and improved ability to communicate pain []. MV is an important factor for delirium and dexmedetomidine was found to be associated with lower risk of delirium [, ]. Prophylactic low-dose dexmedetomidine is able to reduce the occurrence of delirium during the first 7 days after surgery for patients aged over 65 years who are admitted to the ICU after surgery []. Thus, the beneficial effect of might be explained by the reduction of delirium in the treated group. In fact, delirium can be considered as a type of acute organ dysfunction mediated via inflammatory response. There has been evidence that inflammatory biomarkers such as C-reactive protein was positively correlated with the occurrence of delirium []. |
| first_indexed | 2024-03-12T00:33:44Z |
| format | Article |
| id | doaj.art-fd231757cc6242ba92e1e265f35eaff0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:33:44Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-fd231757cc6242ba92e1e265f35eaff02023-09-15T10:07:29ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532020-07-0133658458610.1080/08941939.2018.15424711542471Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction?Zhongheng Zhang0Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDexmedetomidine has been widely used in the intensive care unit (ICU), with the primary aim to keep patients on an appropriate level of sedation. Both observational and randomized controlled trials have observed that the use of dexmedetomidine is associated with improved outcomes for mechanically ventilated patients []. In ICU patients receiving prolonged mechanical ventilation, dexmedetomidine was not inferior to other sedatives in maintaining sedation level, but was associated with shortened MV duration and improved ability to communicate pain []. MV is an important factor for delirium and dexmedetomidine was found to be associated with lower risk of delirium [, ]. Prophylactic low-dose dexmedetomidine is able to reduce the occurrence of delirium during the first 7 days after surgery for patients aged over 65 years who are admitted to the ICU after surgery []. Thus, the beneficial effect of might be explained by the reduction of delirium in the treated group. In fact, delirium can be considered as a type of acute organ dysfunction mediated via inflammatory response. There has been evidence that inflammatory biomarkers such as C-reactive protein was positively correlated with the occurrence of delirium [].http://dx.doi.org/10.1080/08941939.2018.1542471dexmedetomidineacute lung injuryeffectiveness |
| spellingShingle | Zhongheng Zhang Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? Journal of Investigative Surgery dexmedetomidine acute lung injury effectiveness |
| title | Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? |
| title_full | Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? |
| title_fullStr | Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? |
| title_full_unstemmed | Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? |
| title_short | Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction? |
| title_sort | dexmedetomidine for the treatment of acute lung injury a fact or fiction |
| topic | dexmedetomidine acute lung injury effectiveness |
| url | http://dx.doi.org/10.1080/08941939.2018.1542471 |
| work_keys_str_mv | AT zhonghengzhang dexmedetomidineforthetreatmentofacutelunginjuryafactorfiction |