Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study
Until now, in clinical dentistry, antibacterial photodynamic therapy (aPDT) has been restricted to in-office treatments, which hampers repeated applications. This pilot study tested the benefit of a commercially available Lumoral<sup>®</sup> device designed for regular periodontal dual-l...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/44/3/85 |
| _version_ | 1827649567132221440 |
|---|---|
| author | Hanna Lähteenmäki Tommi Pätilä Ismo T. Räisänen Esko Kankuri Taina Tervahartiala Timo Sorsa |
| author_facet | Hanna Lähteenmäki Tommi Pätilä Ismo T. Räisänen Esko Kankuri Taina Tervahartiala Timo Sorsa |
| author_sort | Hanna Lähteenmäki |
| collection | DOAJ |
| description | Until now, in clinical dentistry, antibacterial photodynamic therapy (aPDT) has been restricted to in-office treatments, which hampers repeated applications. This pilot study tested the benefit of a commercially available Lumoral<sup>®</sup> device designed for regular periodontal dual-light aPDT treatment at home. Seven patients with peri-implant disease applied dual-light aPDT daily in addition to their normal dental hygiene for four weeks. A single Lumoral<sup>®</sup> treatment includes an indocyanine green mouth rinse followed by 40 J/cm<sup>2</sup> radiant exposure to a combination of 810 nm and 405 nm light. A point-of-care analysis of active-matrix metalloproteinase (aMMP-8), visible plaque index (VPI), bleeding on probing (BOP), and peri-implant pocket depth (PPD) measurements was performed on day 0, day 15, and day 30. Reductions in aMMP-8 (<i>p</i> = 0.047), VPI (<i>p</i> = 0.03), and BOP (<i>p</i> = 0.03) were observed, and PPD was measured as being 1 mm lower in the implant (<i>p</i> = ns). These results suggest a benefit of regular application of dual-light aPDT in peri-implantitis. Frequently repeated application can be a promising approach to diminishing the microbial burden and to lowering the tissue destructive proteolytic and inflammatory load around dental implants. Further studies in larger populations are warranted to show the long-term benefits. |
| first_indexed | 2024-03-09T19:59:33Z |
| format | Article |
| id | doaj.art-fd236aa7620847d99af007edbf38280f |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T19:59:33Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-fd236aa7620847d99af007edbf38280f2023-11-24T00:48:29ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-03-014431273128310.3390/cimb44030085Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot StudyHanna Lähteenmäki0Tommi Pätilä1Ismo T. Räisänen2Esko Kankuri3Taina Tervahartiala4Timo Sorsa5Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00280 Helsinki, FinlandDepartment of Pediatric Heart Surgery and Organ Transplantation, New Children’s Hospital, Helsinki University, 00100 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00280 Helsinki, FinlandDepartment of Pharmacology, Helsinki University, 00100 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00280 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, 00280 Helsinki, FinlandUntil now, in clinical dentistry, antibacterial photodynamic therapy (aPDT) has been restricted to in-office treatments, which hampers repeated applications. This pilot study tested the benefit of a commercially available Lumoral<sup>®</sup> device designed for regular periodontal dual-light aPDT treatment at home. Seven patients with peri-implant disease applied dual-light aPDT daily in addition to their normal dental hygiene for four weeks. A single Lumoral<sup>®</sup> treatment includes an indocyanine green mouth rinse followed by 40 J/cm<sup>2</sup> radiant exposure to a combination of 810 nm and 405 nm light. A point-of-care analysis of active-matrix metalloproteinase (aMMP-8), visible plaque index (VPI), bleeding on probing (BOP), and peri-implant pocket depth (PPD) measurements was performed on day 0, day 15, and day 30. Reductions in aMMP-8 (<i>p</i> = 0.047), VPI (<i>p</i> = 0.03), and BOP (<i>p</i> = 0.03) were observed, and PPD was measured as being 1 mm lower in the implant (<i>p</i> = ns). These results suggest a benefit of regular application of dual-light aPDT in peri-implantitis. Frequently repeated application can be a promising approach to diminishing the microbial burden and to lowering the tissue destructive proteolytic and inflammatory load around dental implants. Further studies in larger populations are warranted to show the long-term benefits.https://www.mdpi.com/1467-3045/44/3/85antibacterial photodynamic therapyaMMP-8oral hygieneperi-implant disease |
| spellingShingle | Hanna Lähteenmäki Tommi Pätilä Ismo T. Räisänen Esko Kankuri Taina Tervahartiala Timo Sorsa Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study Current Issues in Molecular Biology antibacterial photodynamic therapy aMMP-8 oral hygiene peri-implant disease |
| title | Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study |
| title_full | Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study |
| title_fullStr | Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study |
| title_full_unstemmed | Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study |
| title_short | Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease—A Pilot Study |
| title_sort | repeated home applied dual light antibacterial photodynamic therapy can reduce plaque burden inflammation and ammp 8 in peri implant disease a pilot study |
| topic | antibacterial photodynamic therapy aMMP-8 oral hygiene peri-implant disease |
| url | https://www.mdpi.com/1467-3045/44/3/85 |
| work_keys_str_mv | AT hannalahteenmaki repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy AT tommipatila repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy AT ismotraisanen repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy AT eskokankuri repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy AT tainatervahartiala repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy AT timosorsa repeatedhomeappliedduallightantibacterialphotodynamictherapycanreduceplaqueburdeninflammationandammp8inperiimplantdiseaseapilotstudy |