New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp.
An investigation of the chemical composition of a Formosan soft coral <i>Cespitularia</i> sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (<b>1</b>); one new eudesmane sesquiterpenoid, cespilamide F (<b>2</b>); and three new hydr...
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MDPI AG
2023-02-01
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author | Chung-Wei Fu You-Cheng Lin Shu-Fen Chiou Shu-Li Chen Chi-Chien Lin Hui-Chun Wang Chang-Feng Dai Jyh-Horng Sheu |
author_facet | Chung-Wei Fu You-Cheng Lin Shu-Fen Chiou Shu-Li Chen Chi-Chien Lin Hui-Chun Wang Chang-Feng Dai Jyh-Horng Sheu |
author_sort | Chung-Wei Fu |
collection | DOAJ |
description | An investigation of the chemical composition of a Formosan soft coral <i>Cespitularia</i> sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (<b>1</b>); one new eudesmane sesquiterpenoid, cespilamide F (<b>2</b>); and three new hydroperoxysteroids (<b>3</b>–<b>5</b>) along with twelve known analogous metabolites (<b>6</b>–<b>17</b>). In addition, one new derivative, cespitulactam M-6,2′-diacetate (<b>1a</b>), was prepared from compound <b>1</b>. The structures were determined by detailed spectroscopic analyses, particularly HRESIMS and NMR techniques. Moreover, the in vitro cytotoxicity, anti-inflammatory, and antibacterial activity of <b>1</b>–<b>17</b> and <b>1a</b> were evaluated. |
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issn | 1420-3049 |
language | English |
last_indexed | 2024-03-11T08:22:44Z |
publishDate | 2023-02-01 |
publisher | MDPI AG |
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series | Molecules |
spelling | doaj.art-fd240e80011440b4affc622793a186f62023-11-16T22:19:42ZengMDPI AGMolecules1420-30492023-02-01284152110.3390/molecules28041521New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp.Chung-Wei Fu0You-Cheng Lin1Shu-Fen Chiou2Shu-Li Chen3Chi-Chien Lin4Hui-Chun Wang5Chang-Feng Dai6Jyh-Horng Sheu7Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 402, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanInstitute of Oceanography, National Taiwan University, Taipei 106, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanAn investigation of the chemical composition of a Formosan soft coral <i>Cespitularia</i> sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (<b>1</b>); one new eudesmane sesquiterpenoid, cespilamide F (<b>2</b>); and three new hydroperoxysteroids (<b>3</b>–<b>5</b>) along with twelve known analogous metabolites (<b>6</b>–<b>17</b>). In addition, one new derivative, cespitulactam M-6,2′-diacetate (<b>1a</b>), was prepared from compound <b>1</b>. The structures were determined by detailed spectroscopic analyses, particularly HRESIMS and NMR techniques. Moreover, the in vitro cytotoxicity, anti-inflammatory, and antibacterial activity of <b>1</b>–<b>17</b> and <b>1a</b> were evaluated.https://www.mdpi.com/1420-3049/28/4/1521<i>Cespitularia</i> sp.verticillene diterpenoidseudesmane sesquiterpenoidshydroperoxysteroids |
spellingShingle | Chung-Wei Fu You-Cheng Lin Shu-Fen Chiou Shu-Li Chen Chi-Chien Lin Hui-Chun Wang Chang-Feng Dai Jyh-Horng Sheu New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. Molecules <i>Cespitularia</i> sp. verticillene diterpenoids eudesmane sesquiterpenoids hydroperoxysteroids |
title | New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. |
title_full | New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. |
title_fullStr | New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. |
title_full_unstemmed | New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. |
title_short | New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral <i>Cespitularia</i> sp. |
title_sort | new verticillene diterpenoids eudesmane sesquiterpenoids and hydroperoxysteroids from the further chemical investigation of a taiwanese soft coral i cespitularia i sp |
topic | <i>Cespitularia</i> sp. verticillene diterpenoids eudesmane sesquiterpenoids hydroperoxysteroids |
url | https://www.mdpi.com/1420-3049/28/4/1521 |
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