Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activat...
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MDPI AG
2021-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/16/7646 |
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| author | Sandra Bacián Martínez Carlos Navarro Cuéllar Carlos Navarro Vila Edurne Palacios Weiss Roser Pujol Romanyá Álvaro del Amo Fernández de Velasco Margarita Escrig de Teijeiro José Luis del Castillo Pardo de Vera Irene Rodríguez Pérez Arturo Sánchez-Pérez José J. Zamorano-León Antonio López-Farré María Isabel García-Hidalgo Alonso Ignacio Navarro Cuéllar |
| author_facet | Sandra Bacián Martínez Carlos Navarro Cuéllar Carlos Navarro Vila Edurne Palacios Weiss Roser Pujol Romanyá Álvaro del Amo Fernández de Velasco Margarita Escrig de Teijeiro José Luis del Castillo Pardo de Vera Irene Rodríguez Pérez Arturo Sánchez-Pérez José J. Zamorano-León Antonio López-Farré María Isabel García-Hidalgo Alonso Ignacio Navarro Cuéllar |
| author_sort | Sandra Bacián Martínez |
| collection | DOAJ |
| description | Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC. |
| first_indexed | 2024-03-10T09:01:57Z |
| format | Article |
| id | doaj.art-fd24259bedfb4a02aa9b2c89293eaf4d |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:01:57Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-fd24259bedfb4a02aa9b2c89293eaf4d2023-11-22T06:44:48ZengMDPI AGApplied Sciences2076-34172021-08-011116764610.3390/app11167646Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the JawSandra Bacián Martínez0Carlos Navarro Cuéllar1Carlos Navarro Vila2Edurne Palacios Weiss3Roser Pujol Romanyá4Álvaro del Amo Fernández de Velasco5Margarita Escrig de Teijeiro6José Luis del Castillo Pardo de Vera7Irene Rodríguez Pérez8Arturo Sánchez-Pérez9José J. Zamorano-León10Antonio López-Farré11María Isabel García-Hidalgo Alonso12Ignacio Navarro Cuéllar13Maxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainPathology Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainFaculty of Medicine, Murcia University, 30008 Murcia, SpainFaculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainFaculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainRadiology Department, Hospital Puerta de Hierro, 28222 Madrid, SpainMaxillofacial Surgery Department, Hospital Universitario HLA Moncloa, 28008 Madrid, SpainMedication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.https://www.mdpi.com/2076-3417/11/16/7646denosumabmedication related osteonecrosis of the jaw (MRNOJ)primary intraosseous squamous cell carcinoma |
| spellingShingle | Sandra Bacián Martínez Carlos Navarro Cuéllar Carlos Navarro Vila Edurne Palacios Weiss Roser Pujol Romanyá Álvaro del Amo Fernández de Velasco Margarita Escrig de Teijeiro José Luis del Castillo Pardo de Vera Irene Rodríguez Pérez Arturo Sánchez-Pérez José J. Zamorano-León Antonio López-Farré María Isabel García-Hidalgo Alonso Ignacio Navarro Cuéllar Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw Applied Sciences denosumab medication related osteonecrosis of the jaw (MRNOJ) primary intraosseous squamous cell carcinoma |
| title | Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw |
| title_full | Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw |
| title_fullStr | Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw |
| title_full_unstemmed | Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw |
| title_short | Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw |
| title_sort | intraosseous squamous cell carcinoma associated with denosumab induced osteonecrosis of the jaw |
| topic | denosumab medication related osteonecrosis of the jaw (MRNOJ) primary intraosseous squamous cell carcinoma |
| url | https://www.mdpi.com/2076-3417/11/16/7646 |
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