Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37254-w |
| _version_ | 1797853757902422016 |
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| author | Brian C. Sanders Suman Pokhrel Audrey D. Labbe Irimpan I. Mathews Connor J. Cooper Russell B. Davidson Gwyndalyn Phillips Kevin L. Weiss Qiu Zhang Hugh O’Neill Manat Kaur Jurgen G. Schmidt Walter Reichard Surekha Surendranathan Jyothi Parvathareddy Lexi Phillips Christopher Rainville David E. Sterner Desigan Kumaran Babak Andi Gyorgy Babnigg Nigel W. Moriarty Paul D. Adams Andrzej Joachimiak Brett L. Hurst Suresh Kumar Tauseef R. Butt Colleen B. Jonsson Lori Ferrins Soichi Wakatsuki Stephanie Galanie Martha S. Head Jerry M. Parks |
| author_facet | Brian C. Sanders Suman Pokhrel Audrey D. Labbe Irimpan I. Mathews Connor J. Cooper Russell B. Davidson Gwyndalyn Phillips Kevin L. Weiss Qiu Zhang Hugh O’Neill Manat Kaur Jurgen G. Schmidt Walter Reichard Surekha Surendranathan Jyothi Parvathareddy Lexi Phillips Christopher Rainville David E. Sterner Desigan Kumaran Babak Andi Gyorgy Babnigg Nigel W. Moriarty Paul D. Adams Andrzej Joachimiak Brett L. Hurst Suresh Kumar Tauseef R. Butt Colleen B. Jonsson Lori Ferrins Soichi Wakatsuki Stephanie Galanie Martha S. Head Jerry M. Parks |
| author_sort | Brian C. Sanders |
| collection | DOAJ |
| description | The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells. |
| first_indexed | 2024-04-09T19:54:49Z |
| format | Article |
| id | doaj.art-fd261a622e08487782f550c5d0f5bc31 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:54:49Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fd261a622e08487782f550c5d0f5bc312023-04-03T05:33:32ZengNature PortfolioNature Communications2041-17232023-03-0114111710.1038/s41467-023-37254-wPotent and selective covalent inhibition of the papain-like protease from SARS-CoV-2Brian C. Sanders0Suman Pokhrel1Audrey D. Labbe2Irimpan I. Mathews3Connor J. Cooper4Russell B. Davidson5Gwyndalyn Phillips6Kevin L. Weiss7Qiu Zhang8Hugh O’Neill9Manat Kaur10Jurgen G. Schmidt11Walter Reichard12Surekha Surendranathan13Jyothi Parvathareddy14Lexi Phillips15Christopher Rainville16David E. Sterner17Desigan Kumaran18Babak Andi19Gyorgy Babnigg20Nigel W. Moriarty21Paul D. Adams22Andrzej Joachimiak23Brett L. Hurst24Suresh Kumar25Tauseef R. Butt26Colleen B. Jonsson27Lori Ferrins28Soichi Wakatsuki29Stephanie Galanie30Martha S. Head31Jerry M. Parks32Biosciences Division, Oak Ridge National LaboratoryDepartment of Chemical and Systems Biology, Stanford University School of MedicineBiosciences Division, Oak Ridge National LaboratoryStanford Synchrotron Radiation LightsourceBiosciences Division, Oak Ridge National LaboratoryBiosciences Division, Oak Ridge National LaboratoryNeutron Scattering Division, Oak Ridge National LaboratoryNeutron Scattering Division, Oak Ridge National LaboratoryNeutron Scattering Division, Oak Ridge National LaboratoryNeutron Scattering Division, Oak Ridge National LaboratoryDepartment of Structural Biology, Stanford University School of MedicineB-11 Bioenergy and Biome Sciences, Bioscience Division, Los Alamos National LaboratoryDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science CenterRegional Biocontainment Laboratory, University of Tennessee Health Science CenterRegional Biocontainment Laboratory, University of Tennessee Health Science CenterInstitute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State UniversityProgenra Inc.Progenra Inc.Biology Department, Brookhaven National LaboratoryCenter for BioMolecular Structure, National Synchrotron Light Source II, Brookhaven National LaboratoryCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of ChicagoMolecular Biosciences and Integrated Bioimaging, Lawrence Berkeley National LaboratoryMolecular Biosciences and Integrated Bioimaging, Lawrence Berkeley National LaboratoryCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of ChicagoInstitute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State UniversityProgenra Inc.Progenra Inc.Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science CenterDepartment of Chemistry and Chemical Biology, Northeastern UniversityDepartment of Chemical and Systems Biology, Stanford University School of MedicineBiosciences Division, Oak Ridge National LaboratoryJoint Institute for Biological Sciences, Oak Ridge National LaboratoryBiosciences Division, Oak Ridge National LaboratoryThe development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells.https://doi.org/10.1038/s41467-023-37254-w |
| spellingShingle | Brian C. Sanders Suman Pokhrel Audrey D. Labbe Irimpan I. Mathews Connor J. Cooper Russell B. Davidson Gwyndalyn Phillips Kevin L. Weiss Qiu Zhang Hugh O’Neill Manat Kaur Jurgen G. Schmidt Walter Reichard Surekha Surendranathan Jyothi Parvathareddy Lexi Phillips Christopher Rainville David E. Sterner Desigan Kumaran Babak Andi Gyorgy Babnigg Nigel W. Moriarty Paul D. Adams Andrzej Joachimiak Brett L. Hurst Suresh Kumar Tauseef R. Butt Colleen B. Jonsson Lori Ferrins Soichi Wakatsuki Stephanie Galanie Martha S. Head Jerry M. Parks Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 Nature Communications |
| title | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 |
| title_full | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 |
| title_fullStr | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 |
| title_full_unstemmed | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 |
| title_short | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 |
| title_sort | potent and selective covalent inhibition of the papain like protease from sars cov 2 |
| url | https://doi.org/10.1038/s41467-023-37254-w |
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