Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair

Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair

To improve the efficacy of chemoradiation therapy for locally advanced pancreatic cancer and begin to establish patient selection criteria, we investigated the combination of the WEE1 inhibitor AZD1775 with gemcitabine-radiation in homologous recombination (HR) repair proficient and deficient pancre...

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Bibliographic Details
Main Authors: Tasneem Kausar, Jason S. Schreiber, David Karnak, Leslie A. Parsels, Joshua D. Parsels, Mary A. Davis, Lili Zhao, Jonathan Maybaum, Theodore S. Lawrence, Meredith A. Morgan
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615001190

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