Evaluation of Serum Magnesium, Lipid Profile and Various Biochemical Parameters as Risk Factors of Cardiovascular Diseases in Patients with Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is chronic inflammatory disease, associated with increased risk of cardiovascular diseases (CVD) than the general population. Chronic inflammatory conditions are likely to alter magnesium level and various biochemical parameters. Objectives: To study the pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5740/12206_CE[Ra1]_F(AK)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Background: Rheumatoid arthritis (RA) is chronic inflammatory
disease, associated with increased risk of cardiovascular
diseases (CVD) than the general population. Chronic inflammatory
conditions are likely to alter magnesium level and various
biochemical parameters.
Objectives: To study the probable changes in serum magnesium,
lipid profile and various biochemical parameters and to assess
risk factors of CVD in newly diagnosed RA patients compared
to controls.
Materials and Methods: We studied 50 newly diagnosed RA
adult patients and 50 healthy individuals as controls. Serum
magnesium, calcium, lipid profile, uric acid and other biochemical
parameters were measured in study subjects. Results were
expressed as Mean ± SD and compared between RA subjects and
controls by Independent sample t-test and Pearson correlation.
Results: We found decreased serum magnesium and calcium in
RA subjects compared to the controls (p < 0.001). RA subjects
had atherogenic lipid profile characterized by elevated total
cholesterol (p = 0.054), LDL cholesterol (p = 0.008) and decreased
HDL cholesterol (p < 0.001). Serum uric acid was higher in RA
cases compared to controls (p = 0.025). Serum magnesium was
negatively correlated with total cholesterol, LDL cholesterol and
positively correlated with HDL cholesterol in RA cases.
Conclusion: Decreased magnesium level, dyslipidemia and
increased uric acid observed in our study together may be more
potent risk factors for CVD in newly diagnosed RA subjects. We
recommend that serum magnesium should be investigated as
a part of cardiovascular risk management in RA. We suggest
that decreased serum magnesium and increased serum uric
acid may be considered as nontraditional risk factors of CVD
in RA. Further prospective studies are needed to confirm the
impact of inflammation on various biochemical parameters and
cardiovascular outcomes in patients with RA. |
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| ISSN: | 2249-782X 0973-709X |