TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis
Background: Transient receptor potential cation channel subfamily V member 1 (TRPV1) was considered to play pivotal roles in multiple cancers; however, the expression and clinical significance of the TRPV1 remain unclear, which were explored in this study. Results: The pan-cancer analysis was p...
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| Format: | Article |
| Language: | English |
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AIMS Press
2022-06-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2022389?viewType=HTML |
| _version_ | 1818253600016564224 |
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| author | Tao Huang |
| author_facet | Tao Huang |
| author_sort | Tao Huang |
| collection | DOAJ |
| description | Background:
Transient receptor potential cation channel subfamily V member 1 (TRPV1) was considered to play pivotal roles in multiple cancers; however, the expression and clinical significance of the TRPV1 remain unclear, which were explored in this study.
Results:
The pan-cancer analysis was performed based on 10,236 samples in 32 cancers. Differential TRPV1 expression levels were detected in 12 cancers (p < 0.05). TRPV1 demonstrated its conspicuous prognosis significance and prediction effects for some cancers (e.g., lung adenocarcinoma), indicating its potential as a valuable and novel biomarker in treating and predicting cancers. TRPV1 expression was relevant to DNA methyltransferases, mismatch repair genes, tumor mutational burden, and microsatellite instability. TRPV1 expression was associated with the immune microenvironment of some cancers, and its roles in different cancers may be mediated by affecting various immune cells. Gene set enrichment analysis discloses the significant relevance of TRPV1 expression with a series of metabolic and immunoregulatory-related pathways.
Conclusions:
This study provided a comprehensive workflow of the expression, clinical significance, and underlying mechanisms of TRPV1 in pan-cancer. TRPV1 may be an underlying biomarker for predicting and treating multiple cancer. |
| first_indexed | 2024-12-12T16:42:39Z |
| format | Article |
| id | doaj.art-fd276028ef984af9a1d22545ce3f2720 |
| institution | Directory Open Access Journal |
| issn | 1551-0018 |
| language | English |
| last_indexed | 2024-12-12T16:42:39Z |
| publishDate | 2022-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj.art-fd276028ef984af9a1d22545ce3f27202022-12-22T00:18:33ZengAIMS PressMathematical Biosciences and Engineering1551-00182022-06-011988361837910.3934/mbe.2022389TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysisTao Huang0Department of Cardiothoracic Vascular Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaBackground: Transient receptor potential cation channel subfamily V member 1 (TRPV1) was considered to play pivotal roles in multiple cancers; however, the expression and clinical significance of the TRPV1 remain unclear, which were explored in this study. Results: The pan-cancer analysis was performed based on 10,236 samples in 32 cancers. Differential TRPV1 expression levels were detected in 12 cancers (p < 0.05). TRPV1 demonstrated its conspicuous prognosis significance and prediction effects for some cancers (e.g., lung adenocarcinoma), indicating its potential as a valuable and novel biomarker in treating and predicting cancers. TRPV1 expression was relevant to DNA methyltransferases, mismatch repair genes, tumor mutational burden, and microsatellite instability. TRPV1 expression was associated with the immune microenvironment of some cancers, and its roles in different cancers may be mediated by affecting various immune cells. Gene set enrichment analysis discloses the significant relevance of TRPV1 expression with a series of metabolic and immunoregulatory-related pathways. Conclusions: This study provided a comprehensive workflow of the expression, clinical significance, and underlying mechanisms of TRPV1 in pan-cancer. TRPV1 may be an underlying biomarker for predicting and treating multiple cancer.https://www.aimspress.com/article/doi/10.3934/mbe.2022389?viewType=HTMLcancer biologycancer geneticsprognosisimmunologybiomarkers |
| spellingShingle | Tao Huang TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis Mathematical Biosciences and Engineering cancer biology cancer genetics prognosis immunology biomarkers |
| title | TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis |
| title_full | TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis |
| title_fullStr | TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis |
| title_full_unstemmed | TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis |
| title_short | TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis |
| title_sort | trpv1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan cancer analysis |
| topic | cancer biology cancer genetics prognosis immunology biomarkers |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2022389?viewType=HTML |
| work_keys_str_mv | AT taohuang trpv1isapotentialbiomarkerforthepredictionandtreatmentofmultiplecancersbasedonapancanceranalysis |