Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis
Objective: This study was designed to determine the association curcumin has on pro-inflammatory biomarkers in patients with chronic kidney disease (CKD (and in those receiving hemodialysis (HD).Materials and Methods: This meta-analysis was undertaken following PRISMA guidelines. An extensive system...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2022-11-01
|
| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_20049_55fce7d8a59c2e930b07c8eb7e2e6f4e.pdf |
| _version_ | 1811247985895407616 |
|---|---|
| author | Elham Emami Saeid Heidari-Soureshjani Catherine Sherwin |
| author_facet | Elham Emami Saeid Heidari-Soureshjani Catherine Sherwin |
| author_sort | Elham Emami |
| collection | DOAJ |
| description | Objective: This study was designed to determine the association curcumin has on pro-inflammatory biomarkers in patients with chronic kidney disease (CKD (and in those receiving hemodialysis (HD).Materials and Methods: This meta-analysis was undertaken following PRISMA guidelines. An extensive systematic review was undertaken until 10/11/2021 using PubMed, Web of Science (ISI), and Scopus databases. The standardized mean difference (SMD) and 95% confidence intervals (CI) were used to estimate the overall effect size of curcumin on serum high-sensitivity C-reactive protein (hs-CRP), and pro-inflammatory cytokines including interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in patients with CKD and those receiving HD.Results: Overall, ten randomized controlled trials (RCTs) comprising 523 patients were incorporated into the systematic review and meta-analysis. The results showed that when compared with control groups, there was no significant effect observed linking curcumin and IL-6 (SMD = 0.24%, 95% CI = -0.14 to 0.62, p = 0.221), TNF-α (SMD = 0.11%, 95% CI = -0.19 to 0.40, p = 0.480) or hs-CRP (SMD = -0.17%, 95% CI = -0.36 to 0.03, p = 0.093). The analysis determined no publication bias related to the influence of curcumin on IL-6, TNF-α or acute phase reactant, hs-CRP. The Egger’s and Begg’s test results were not statistically significant (p˃0.20).Conclusion: In patients with CKD and those receiving HD, the use of curcumin supplementation has no statistically significant effect on the anti-inflammatory biomarkers reviewed in this study. |
| first_indexed | 2024-04-12T15:19:05Z |
| format | Article |
| id | doaj.art-fd28b12995f646f49410b7511946493a |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T15:19:05Z |
| publishDate | 2022-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-fd28b12995f646f49410b7511946493a2022-12-22T03:27:32ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492022-11-0112657658810.22038/ajp.2022.2004920049Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysisElham Emami0Saeid Heidari-Soureshjani1Catherine Sherwin2Department of Pediatric Nephrology, Emam Hossein Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranModeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Pediatric Clinical Pharmacology, Department of Pharmacology & Toxicology, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital, One Children's Plaza, Dayton, Ohio, USAObjective: This study was designed to determine the association curcumin has on pro-inflammatory biomarkers in patients with chronic kidney disease (CKD (and in those receiving hemodialysis (HD).Materials and Methods: This meta-analysis was undertaken following PRISMA guidelines. An extensive systematic review was undertaken until 10/11/2021 using PubMed, Web of Science (ISI), and Scopus databases. The standardized mean difference (SMD) and 95% confidence intervals (CI) were used to estimate the overall effect size of curcumin on serum high-sensitivity C-reactive protein (hs-CRP), and pro-inflammatory cytokines including interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in patients with CKD and those receiving HD.Results: Overall, ten randomized controlled trials (RCTs) comprising 523 patients were incorporated into the systematic review and meta-analysis. The results showed that when compared with control groups, there was no significant effect observed linking curcumin and IL-6 (SMD = 0.24%, 95% CI = -0.14 to 0.62, p = 0.221), TNF-α (SMD = 0.11%, 95% CI = -0.19 to 0.40, p = 0.480) or hs-CRP (SMD = -0.17%, 95% CI = -0.36 to 0.03, p = 0.093). The analysis determined no publication bias related to the influence of curcumin on IL-6, TNF-α or acute phase reactant, hs-CRP. The Egger’s and Begg’s test results were not statistically significant (p˃0.20).Conclusion: In patients with CKD and those receiving HD, the use of curcumin supplementation has no statistically significant effect on the anti-inflammatory biomarkers reviewed in this study.https://ajp.mums.ac.ir/article_20049_55fce7d8a59c2e930b07c8eb7e2e6f4e.pdfchronic kidney diseasehemodialysiscurcumininflammation |
| spellingShingle | Elham Emami Saeid Heidari-Soureshjani Catherine Sherwin Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis Avicenna Journal of Phytomedicine chronic kidney disease hemodialysis curcumin inflammation |
| title | Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis |
| title_full | Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis |
| title_fullStr | Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis |
| title_full_unstemmed | Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis |
| title_short | Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis |
| title_sort | anti inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients a systematic review and meta analysis |
| topic | chronic kidney disease hemodialysis curcumin inflammation |
| url | https://ajp.mums.ac.ir/article_20049_55fce7d8a59c2e930b07c8eb7e2e6f4e.pdf |
| work_keys_str_mv | AT elhamemami antiinflammatoryresponsetocurcuminsupplementationinchronickidneydiseaseandhemodialysispatientsasystematicreviewandmetaanalysis AT saeidheidarisoureshjani antiinflammatoryresponsetocurcuminsupplementationinchronickidneydiseaseandhemodialysispatientsasystematicreviewandmetaanalysis AT catherinesherwin antiinflammatoryresponsetocurcuminsupplementationinchronickidneydiseaseandhemodialysispatientsasystematicreviewandmetaanalysis |