Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania
<i>Background and Objectives:</i> The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/2/275 |
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| author | Simona Claudia Cambrea Eugenia Andreea Marcu Elena Cucli Diana Badiu Roxana Penciu Cristian Lucian Petcu Elena Dumea Stela Halichidis Loredana Pazara Cristina Maria Mihai Florentina Dumitrescu |
| author_facet | Simona Claudia Cambrea Eugenia Andreea Marcu Elena Cucli Diana Badiu Roxana Penciu Cristian Lucian Petcu Elena Dumea Stela Halichidis Loredana Pazara Cristina Maria Mihai Florentina Dumitrescu |
| author_sort | Simona Claudia Cambrea |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two HIV-acquired immune deficiency syndrome (AIDS) Regional Centers (RCs), Constanta and Craiova in Romania. <i>Materials and Methods:</i> During the study period (2008–2019), 408 HIV-positive pregnant women, 244 from Constanta RC and 164 from Craiova RC who attended antenatal visits, were included. All HIV-positive pregnant women were under combined antiretroviral therapy (cART) during pregnancy and childbirth, being followedup with their infants up to 18 months after delivery. We investigated the clinical as well as biological risk factorsassociated with increased MTCT of HIV. <i>Results:</i> Comparing different variables of HIV-positive pregnant women from the two HIV-AIDS CRs, we find that there are significant differences between the mean value of hemoglobin, CD4 level, environmental area, marital and amniotic membranes status, and HIV patient stage in the last trimester of pregnancy (<i>p</i> < 0.05), but without any differences in mother’s mean age, education level, type of delivery, breastfeeding, the duration of cART administration, HIV viral load, and survival rate. <i>Conclusions:</i> In 408 HIV-positive pregnant women followed up at two HIV-AIDS RCs in Romania, the most important clinical and biological risk factors associated with increased MTCT of HIV are represented by anemia, CD4 level, and HIV patient stage. |
| first_indexed | 2024-03-09T21:30:04Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T21:30:04Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-fd292629c6de42ba9d2532b5766df1112023-11-23T21:00:47ZengMDPI AGMedicina1010-660X1648-91442022-02-0158227510.3390/medicina58020275Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in RomaniaSimona Claudia Cambrea0Eugenia Andreea Marcu1Elena Cucli2Diana Badiu3Roxana Penciu4Cristian Lucian Petcu5Elena Dumea6Stela Halichidis7Loredana Pazara8Cristina Maria Mihai9Florentina Dumitrescu10Faculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaCraiova Clinical Hospital of Infectious Diseases and Pneumophthisiology “Victor Babeș”, 200515 Craiova, RomaniaClinical Infectious Diseases Hospital from Constanta, 900709 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaStatistical Department, Faculty of Dental Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University from Constanta, 900470 Constanta, RomaniaCraiova Clinical Hospital of Infectious Diseases and Pneumophthisiology “Victor Babeș”, 200515 Craiova, Romania<i>Background and Objectives:</i> The occurrence of human immunodeficiency virus (HIV) infection in children in Romania has been reported since 1989. This retrospective study was aimed at assessing clinical and biological risk factors for mother-to-child transmission (MTCT) of HIV in two HIV-acquired immune deficiency syndrome (AIDS) Regional Centers (RCs), Constanta and Craiova in Romania. <i>Materials and Methods:</i> During the study period (2008–2019), 408 HIV-positive pregnant women, 244 from Constanta RC and 164 from Craiova RC who attended antenatal visits, were included. All HIV-positive pregnant women were under combined antiretroviral therapy (cART) during pregnancy and childbirth, being followedup with their infants up to 18 months after delivery. We investigated the clinical as well as biological risk factorsassociated with increased MTCT of HIV. <i>Results:</i> Comparing different variables of HIV-positive pregnant women from the two HIV-AIDS CRs, we find that there are significant differences between the mean value of hemoglobin, CD4 level, environmental area, marital and amniotic membranes status, and HIV patient stage in the last trimester of pregnancy (<i>p</i> < 0.05), but without any differences in mother’s mean age, education level, type of delivery, breastfeeding, the duration of cART administration, HIV viral load, and survival rate. <i>Conclusions:</i> In 408 HIV-positive pregnant women followed up at two HIV-AIDS RCs in Romania, the most important clinical and biological risk factors associated with increased MTCT of HIV are represented by anemia, CD4 level, and HIV patient stage.https://www.mdpi.com/1648-9144/58/2/275risk factorshemoglobinHIV patientsdeliverymother-to-child transmission |
| spellingShingle | Simona Claudia Cambrea Eugenia Andreea Marcu Elena Cucli Diana Badiu Roxana Penciu Cristian Lucian Petcu Elena Dumea Stela Halichidis Loredana Pazara Cristina Maria Mihai Florentina Dumitrescu Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania Medicina risk factors hemoglobin HIV patients delivery mother-to-child transmission |
| title | Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania |
| title_full | Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania |
| title_fullStr | Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania |
| title_full_unstemmed | Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania |
| title_short | Clinical and Biological Risk Factors Associated with Increased Mother-to-Child Transmission of HIV in Two South-East HIV-AIDS Regional Centers in Romania |
| title_sort | clinical and biological risk factors associated with increased mother to child transmission of hiv in two south east hiv aids regional centers in romania |
| topic | risk factors hemoglobin HIV patients delivery mother-to-child transmission |
| url | https://www.mdpi.com/1648-9144/58/2/275 |
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