Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region
Abstract The Asia–Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-07-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12936-020-03330-5 |
| _version_ | 1811287979811930112 |
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| author | Rintis Noviyanti Olivo Miotto Alyssa Barry Jutta Marfurt Sasha Siegel Nguyen Thuy-Nhien Huynh Hong Quang Nancy Dian Anggraeni Ferdinand Laihad Yaobao Liu Maria Endang Sumiwi Hidayat Trimarsanto Farah Coutrier Nadia Fadila Najia Ghanchi Fatema Tuj Johora Agatha Mia Puspitasari Livingstone Tavul Leily Trianty Retno Ayu Setya Utami Duoquan Wang Kesang Wangchuck Ric N. Price Sarah Auburn |
| author_facet | Rintis Noviyanti Olivo Miotto Alyssa Barry Jutta Marfurt Sasha Siegel Nguyen Thuy-Nhien Huynh Hong Quang Nancy Dian Anggraeni Ferdinand Laihad Yaobao Liu Maria Endang Sumiwi Hidayat Trimarsanto Farah Coutrier Nadia Fadila Najia Ghanchi Fatema Tuj Johora Agatha Mia Puspitasari Livingstone Tavul Leily Trianty Retno Ayu Setya Utami Duoquan Wang Kesang Wangchuck Ric N. Price Sarah Auburn |
| author_sort | Rintis Noviyanti |
| collection | DOAJ |
| description | Abstract The Asia–Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes (NMCPs) in decision-making processes. In November 2019 a parasite genotyping workshop was held in Jakarta, Indonesia, to review molecular approaches for parasite surveillance and explore ways in which these tools can be integrated into public health systems and inform policy. The meeting was attended by 70 participants from 8 malaria-endemic countries and partners of the Asia Pacific Malaria Elimination Network. The participants acknowledged the utility of multiple use cases for parasite genotyping including: quantifying the prevalence of drug resistant parasites, predicting risks of treatment failure, identifying major routes and reservoirs of infection, monitoring imported malaria and its contribution to local transmission, characterizing the origins and dynamics of malaria outbreaks, and estimating the frequency of Plasmodium vivax relapses. However, the priority of each use case varies with different endemic settings. Although a one-size-fits-all approach to molecular surveillance is unlikely to be applicable across the Asia–Pacific region, consensus on the spectrum of added-value activities will help support data sharing across national boundaries. Knowledge exchange is needed to establish local expertise in different laboratory-based methodologies and bioinformatics processes. Collaborative research involving local and international teams will help maximize the impact of analytical outputs on the operational needs of NMCPs. Research is also needed to explore the cost-effectiveness of genetic epidemiology for different use cases to help to leverage funding for wide-scale implementation. Engagement between NMCPs and local researchers will be critical throughout this process. |
| first_indexed | 2024-04-13T03:28:59Z |
| format | Article |
| id | doaj.art-fd29a6785dee4e92b92e0a1a593cbaff |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-13T03:28:59Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-fd29a6785dee4e92b92e0a1a593cbaff2022-12-22T03:04:34ZengBMCMalaria Journal1475-28752020-07-0119112010.1186/s12936-020-03330-5Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific regionRintis Noviyanti0Olivo Miotto1Alyssa Barry2Jutta Marfurt3Sasha Siegel4Nguyen Thuy-Nhien5Huynh Hong Quang6Nancy Dian Anggraeni7Ferdinand Laihad8Yaobao Liu9Maria Endang Sumiwi10Hidayat Trimarsanto11Farah Coutrier12Nadia Fadila13Najia Ghanchi14Fatema Tuj Johora15Agatha Mia Puspitasari16Livingstone Tavul17Leily Trianty18Retno Ayu Setya Utami19Duoquan Wang20Kesang Wangchuck21Ric N. Price22Sarah Auburn23Eijkman Institute for Molecular BiologyMahidol‐Oxford Tropical Medicine Research Unit, Mahidol UniversitySchool of Medicine, Deakin UniversityGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin UniversityWellcome Sanger InstituteCentre for Tropical Medicine, Oxford University Clinical Research UnitInstitute of Malariology, Parasitology and EntomologyNational Malaria Control Programme, Ministry of HealthUNICEF Indonesia Country OfficeNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic DiseasesUNICEF Indonesia Country OfficeEijkman Institute for Molecular BiologyEijkman Institute for Molecular BiologyEijkman Institute for Molecular BiologyPathology, Aga Khan University HospitalInfectious Diseases Division, International Centre for Diarrheal Diseases ResearchEijkman Institute for Molecular BiologyPapua New Guinea Institute of Medical ResearchEijkman Institute for Molecular BiologyEijkman Institute for Molecular BiologyNational Institute of Parasitic Diseases, Chinese Center for Disease Control and PreventionRoyal Center for Disease Control, Department of Public Health, Ministry of HealthMahidol‐Oxford Tropical Medicine Research Unit, Mahidol UniversityMahidol‐Oxford Tropical Medicine Research Unit, Mahidol UniversityAbstract The Asia–Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria transmission and adaptation, which can inform national malaria control programmes (NMCPs) in decision-making processes. In November 2019 a parasite genotyping workshop was held in Jakarta, Indonesia, to review molecular approaches for parasite surveillance and explore ways in which these tools can be integrated into public health systems and inform policy. The meeting was attended by 70 participants from 8 malaria-endemic countries and partners of the Asia Pacific Malaria Elimination Network. The participants acknowledged the utility of multiple use cases for parasite genotyping including: quantifying the prevalence of drug resistant parasites, predicting risks of treatment failure, identifying major routes and reservoirs of infection, monitoring imported malaria and its contribution to local transmission, characterizing the origins and dynamics of malaria outbreaks, and estimating the frequency of Plasmodium vivax relapses. However, the priority of each use case varies with different endemic settings. Although a one-size-fits-all approach to molecular surveillance is unlikely to be applicable across the Asia–Pacific region, consensus on the spectrum of added-value activities will help support data sharing across national boundaries. Knowledge exchange is needed to establish local expertise in different laboratory-based methodologies and bioinformatics processes. Collaborative research involving local and international teams will help maximize the impact of analytical outputs on the operational needs of NMCPs. Research is also needed to explore the cost-effectiveness of genetic epidemiology for different use cases to help to leverage funding for wide-scale implementation. Engagement between NMCPs and local researchers will be critical throughout this process.http://link.springer.com/article/10.1186/s12936-020-03330-5Plasmodium falciparumPlasmodium vivaxMalariaSurveillanceMolecular surveillanceGenotyping |
| spellingShingle | Rintis Noviyanti Olivo Miotto Alyssa Barry Jutta Marfurt Sasha Siegel Nguyen Thuy-Nhien Huynh Hong Quang Nancy Dian Anggraeni Ferdinand Laihad Yaobao Liu Maria Endang Sumiwi Hidayat Trimarsanto Farah Coutrier Nadia Fadila Najia Ghanchi Fatema Tuj Johora Agatha Mia Puspitasari Livingstone Tavul Leily Trianty Retno Ayu Setya Utami Duoquan Wang Kesang Wangchuck Ric N. Price Sarah Auburn Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region Malaria Journal Plasmodium falciparum Plasmodium vivax Malaria Surveillance Molecular surveillance Genotyping |
| title | Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region |
| title_full | Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region |
| title_fullStr | Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region |
| title_full_unstemmed | Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region |
| title_short | Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region |
| title_sort | implementing parasite genotyping into national surveillance frameworks feedback from control programmes and researchers in the asia pacific region |
| topic | Plasmodium falciparum Plasmodium vivax Malaria Surveillance Molecular surveillance Genotyping |
| url | http://link.springer.com/article/10.1186/s12936-020-03330-5 |
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