The Clonal Diversity of Peripheral B Cell Receptor Immune Repertoire Impaired by Residual Malignant B Cells Predicts Treatment Efficacy in B Cell Lymphoma Patients

The Clonal Diversity of Peripheral B Cell Receptor Immune Repertoire Impaired by Residual Malignant B Cells Predicts Treatment Efficacy in B Cell Lymphoma Patients

Germinal center (GC) is the vital locus for the evolution of naïve B cells into memory B and plasma cells, but also a hotbed for the proliferation of malignant B cells. We hypothesized that malignant B cells may locally or globally impact GCs to produce peripheral B cell receptor immune repertoire (...

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Bibliographic Details
Main Authors: Meng Wu, Jing Zhang, Yi Wang, Lan Mi, Xiaopei Wang, Weiping Liu, Jie Fu, Haifeng Song, Yuqin Song, Jun Zhu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
germinal center
B cell receptor immune repertoire
B cell lymphoma
clonal diversity
somatic hypermutation
Online Access:https://www.mdpi.com/2072-6694/14/19/4628

Internet

https://www.mdpi.com/2072-6694/14/19/4628

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