Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR
Background: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI. Methods: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplas...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2016.1270162 |
| _version_ | 1797685116925902848 |
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| author | Ott Saluveer Björn Redfors Oskar Angerås Christian Dworeck Inger Haraldsson Charlotta Ljungman Petur Petursson Jacob Odenstedt Dan Ioanes Peter Lundgren Sebastian Völz Truls Råmunddal Bert Andersson Elmir Omerovic Niklas Bergh |
| author_facet | Ott Saluveer Björn Redfors Oskar Angerås Christian Dworeck Inger Haraldsson Charlotta Ljungman Petur Petursson Jacob Odenstedt Dan Ioanes Peter Lundgren Sebastian Völz Truls Råmunddal Bert Andersson Elmir Omerovic Niklas Bergh |
| author_sort | Ott Saluveer |
| collection | DOAJ |
| description | Background: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI. Methods: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris. We used Cox proportional-hazards regression for statistical modelling on complete-case data as well as on imputed data sets. We used interaction test to evaluate possible effect-modulation of hypertension on risk estimates in several pre-specified subgroups: age categories, gender, diabetes, smoking and indication for PCI (STEMI, NSTEMI/UA and stable angina). Results: During the study period, 175,892 consecutive patients underwent coronary angiography due to STEMI, NSTEMI/UA or stable angina. 78,100 (44%) of these had hypertension. Median follow-up was 5.5 years. After adjustment for differences in patient’s characteristics, hypertension was associated with increased risk for mortality (HR 1.12, 95% CI 1.09–1.15, p < .001). In subgroup analysis, risk was highest in patients less than 65 years, in smokers and in patients with STEMI. The risk was lowest in patients with stable angina (p < .001 for interaction test). Conclusion: Hypertension is associated with higher mortality in patients with STEMI, NSTEMI/UA or stable angina who are treated with PCI. |
| first_indexed | 2024-03-12T00:40:49Z |
| format | Article |
| id | doaj.art-fd2a997ea7434004a28298ccd2d961af |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:40:49Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-fd2a997ea7434004a28298ccd2d961af2023-09-15T08:45:21ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992017-05-0126316617310.1080/08037051.2016.12701621270162Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAROtt Saluveer0Björn Redfors1Oskar Angerås2Christian Dworeck3Inger Haraldsson4Charlotta Ljungman5Petur Petursson6Jacob Odenstedt7Dan Ioanes8Peter Lundgren9Sebastian Völz10Truls Råmunddal11Bert Andersson12Elmir Omerovic13Niklas Bergh14Sahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalSahlgrenska University HospitalBackground: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI. Methods: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris. We used Cox proportional-hazards regression for statistical modelling on complete-case data as well as on imputed data sets. We used interaction test to evaluate possible effect-modulation of hypertension on risk estimates in several pre-specified subgroups: age categories, gender, diabetes, smoking and indication for PCI (STEMI, NSTEMI/UA and stable angina). Results: During the study period, 175,892 consecutive patients underwent coronary angiography due to STEMI, NSTEMI/UA or stable angina. 78,100 (44%) of these had hypertension. Median follow-up was 5.5 years. After adjustment for differences in patient’s characteristics, hypertension was associated with increased risk for mortality (HR 1.12, 95% CI 1.09–1.15, p < .001). In subgroup analysis, risk was highest in patients less than 65 years, in smokers and in patients with STEMI. The risk was lowest in patients with stable angina (p < .001 for interaction test). Conclusion: Hypertension is associated with higher mortality in patients with STEMI, NSTEMI/UA or stable angina who are treated with PCI.http://dx.doi.org/10.1080/08037051.2016.1270162acute coronary syndromepcisurvivalhypertensionswedish coronary angiography and angioplasty registry |
| spellingShingle | Ott Saluveer Björn Redfors Oskar Angerås Christian Dworeck Inger Haraldsson Charlotta Ljungman Petur Petursson Jacob Odenstedt Dan Ioanes Peter Lundgren Sebastian Völz Truls Råmunddal Bert Andersson Elmir Omerovic Niklas Bergh Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR Blood Pressure acute coronary syndrome pci survival hypertension swedish coronary angiography and angioplasty registry |
| title | Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR |
| title_full | Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR |
| title_fullStr | Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR |
| title_full_unstemmed | Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR |
| title_short | Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR |
| title_sort | hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention a report from scaar |
| topic | acute coronary syndrome pci survival hypertension swedish coronary angiography and angioplasty registry |
| url | http://dx.doi.org/10.1080/08037051.2016.1270162 |
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