Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) patients often have sleep and mood disorders. Brain-derived neurotrophic factor (BDNF) and proBDNF were shown to modulate interactions between the central nervous system and the gastrointestinal tract, possibly contributing to psychological issues. Anti-tumor necrosi...
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MDPI AG
2023-03-01
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| Online Access: | https://www.mdpi.com/2218-1989/13/3/450 |
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| author | Marcin Sochal Marta Ditmer Agata Binienda Agata Gabryelska Piotr Białasiewicz Renata Talar-Wojnarowska Jakub Fichna Ewa Małecka-Wojciesko |
| author_facet | Marcin Sochal Marta Ditmer Agata Binienda Agata Gabryelska Piotr Białasiewicz Renata Talar-Wojnarowska Jakub Fichna Ewa Małecka-Wojciesko |
| author_sort | Marcin Sochal |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) patients often have sleep and mood disorders. Brain-derived neurotrophic factor (BDNF) and proBDNF were shown to modulate interactions between the central nervous system and the gastrointestinal tract, possibly contributing to psychological issues. Anti-tumor necrosis factor (TNF) therapy in IBD can alter BDNF expression and further affect the brain–gut axis. Eighty IBD patients and 44 healthy controls (HCs) were enrolled and divided into subsets based on disease activity and condition (ulcerative colitis (UC)/Crohn’s disease (CD)). Questionnaires evaluating sleep parameters and depression as well as venous blood were collected. The IBD group had a lower expression of BDNF mRNA, but higher proBDNF and BDNF protein concentration than HCs. The UC group had a higher BDNF protein concentration than the CD. BDNF protein was positively correlated to sleep efficiency in the IBD group. Depression severity was associated positively with BDNF mRNA and negatively with BDNF protein in the remission group. Anti-TNF therapy enhanced BDNF mRNA expression. The BDNF pathway might be disturbed in IBD, linking it to sleep disorders and depression. Systemic inflammation could be the main cause of this disruption. BDNF mRNA is a more reliable parameter than protein due to numerous post-translational modifications. |
| first_indexed | 2024-03-11T06:11:55Z |
| format | Article |
| id | doaj.art-fd2aa86830db412aa15f32bb2134e152 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:55Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-fd2aa86830db412aa15f32bb2134e1522023-11-17T12:37:39ZengMDPI AGMetabolites2218-19892023-03-0113345010.3390/metabo13030450Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel DiseaseMarcin Sochal0Marta Ditmer1Agata Binienda2Agata Gabryelska3Piotr Białasiewicz4Renata Talar-Wojnarowska5Jakub Fichna6Ewa Małecka-Wojciesko7Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Biochemistry, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Digestive Tract Diseases, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Biochemistry, Medical University of Lodz, 90-419 Lodz, PolandDepartment of Digestive Tract Diseases, Medical University of Lodz, 92-215 Lodz, PolandInflammatory bowel disease (IBD) patients often have sleep and mood disorders. Brain-derived neurotrophic factor (BDNF) and proBDNF were shown to modulate interactions between the central nervous system and the gastrointestinal tract, possibly contributing to psychological issues. Anti-tumor necrosis factor (TNF) therapy in IBD can alter BDNF expression and further affect the brain–gut axis. Eighty IBD patients and 44 healthy controls (HCs) were enrolled and divided into subsets based on disease activity and condition (ulcerative colitis (UC)/Crohn’s disease (CD)). Questionnaires evaluating sleep parameters and depression as well as venous blood were collected. The IBD group had a lower expression of BDNF mRNA, but higher proBDNF and BDNF protein concentration than HCs. The UC group had a higher BDNF protein concentration than the CD. BDNF protein was positively correlated to sleep efficiency in the IBD group. Depression severity was associated positively with BDNF mRNA and negatively with BDNF protein in the remission group. Anti-TNF therapy enhanced BDNF mRNA expression. The BDNF pathway might be disturbed in IBD, linking it to sleep disorders and depression. Systemic inflammation could be the main cause of this disruption. BDNF mRNA is a more reliable parameter than protein due to numerous post-translational modifications.https://www.mdpi.com/2218-1989/13/3/450IBDBDNFanti-TNF therapysleepdepression |
| spellingShingle | Marcin Sochal Marta Ditmer Agata Binienda Agata Gabryelska Piotr Białasiewicz Renata Talar-Wojnarowska Jakub Fichna Ewa Małecka-Wojciesko Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease Metabolites IBD BDNF anti-TNF therapy sleep depression |
| title | Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease |
| title_full | Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease |
| title_fullStr | Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease |
| title_full_unstemmed | Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease |
| title_short | Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease |
| title_sort | relation between selected sleep parameters depression anti tumor necrosis factor therapy and the brain derived neurotrophic factor pathway in inflammatory bowel disease |
| topic | IBD BDNF anti-TNF therapy sleep depression |
| url | https://www.mdpi.com/2218-1989/13/3/450 |
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