Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway

Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway

Polymerase δ-interacting protein 2 (Poldip2) has been reported to mediate acute lung injury (ALI); however, the underlying mechanism is not fully explored. Male C57BL/6 mice and A549 cells were used to establish the lipopolysaccharide (LPS)-induced ALI model, then the expression of Poldip2 and its e...

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Bibliographic Details
Main Authors: Yueguo Wang, Wenwen Wang, Shusheng Zhou, Yulan Wang, Obed Cudjoe, Yu Cha, Chunyan Wang, Xiaoguang Cao, Wei Liu, Kui Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
Poldip2
acute lung injury
LPS
oxidative stress
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.958916/full

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