Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA binding domains similar to several paired class homeotic transcription...

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Bibliographic Details
Main Authors: Premi Haynes, Kelly Kernan, Suk-Lin Zhou, Daniel G. Miller
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Skeletal Muscle
Subjects:
Facioscapulohumeral
FSHD
DUX4
PAX7
PAX3
Myogenesis
Online Access:http://link.springer.com/article/10.1186/s13395-017-0130-1

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