Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report
We report a rare case of a 69-year-old woman in whom diffuse large B-cell lymphoma (DLBCL) originated from the uterus and involved the urinary bladder. The cervical smears of the case mostly consisted of discohesive atypical round cells, which were highly suggestive of lymphoma; however, in voided u...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Cytology |
| Subjects: | |
| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=3;spage=181;epage=183;aulast=Adachi |
| _version_ | 1811200697072353280 |
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| author | Sumiyo Adachi Kazuto Yamazaki Shan-Guang Liang Yasuo Ishida |
| author_facet | Sumiyo Adachi Kazuto Yamazaki Shan-Guang Liang Yasuo Ishida |
| author_sort | Sumiyo Adachi |
| collection | DOAJ |
| description | We report a rare case of a 69-year-old woman in whom diffuse large B-cell lymphoma (DLBCL) originated from the uterus and involved the urinary bladder. The cervical smears of the case mostly consisted of discohesive atypical round cells, which were highly suggestive of lymphoma; however, in voided urine smears, a majority of the cells formed large aggregates of degenerated cells, mimicking those of urothelial carcinoma (UC). The smears also represented some small loose clusters, in which tumor cells formed short chains with nuclear molding, mimicking those of small cell carcinoma. The cytodiagnosis got definitive when we identified the atypical cells that showed CD20+/CD3-/cytokeratin-/NSE- immunophenotype. These are of particular concern as they may have misleading similarities to other epithelial neoplasms when examining lymphoma involving the urinary bladder. Accordingly, this case highlights the importance of immunocytochemistry to rule out malignant lymphoma when encountering large and/or small loose clusters of atypical round cells on urinary cytology. |
| first_indexed | 2024-04-12T02:08:34Z |
| format | Article |
| id | doaj.art-fd2e5a4943f74f2f8a0fa01e7b512c92 |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-04-12T02:08:34Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-fd2e5a4943f74f2f8a0fa01e7b512c922022-12-22T03:52:28ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712015-01-0132318118310.4103/0970-9371.168845Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case reportSumiyo AdachiKazuto YamazakiShan-Guang LiangYasuo IshidaWe report a rare case of a 69-year-old woman in whom diffuse large B-cell lymphoma (DLBCL) originated from the uterus and involved the urinary bladder. The cervical smears of the case mostly consisted of discohesive atypical round cells, which were highly suggestive of lymphoma; however, in voided urine smears, a majority of the cells formed large aggregates of degenerated cells, mimicking those of urothelial carcinoma (UC). The smears also represented some small loose clusters, in which tumor cells formed short chains with nuclear molding, mimicking those of small cell carcinoma. The cytodiagnosis got definitive when we identified the atypical cells that showed CD20+/CD3-/cytokeratin-/NSE- immunophenotype. These are of particular concern as they may have misleading similarities to other epithelial neoplasms when examining lymphoma involving the urinary bladder. Accordingly, this case highlights the importance of immunocytochemistry to rule out malignant lymphoma when encountering large and/or small loose clusters of atypical round cells on urinary cytology.http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=3;spage=181;epage=183;aulast=AdachiImmunocytochemistry; lymphoma; urinary bladder; urine; uterine cervix |
| spellingShingle | Sumiyo Adachi Kazuto Yamazaki Shan-Guang Liang Yasuo Ishida Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report Journal of Cytology Immunocytochemistry; lymphoma; urinary bladder; urine; uterine cervix |
| title | Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report |
| title_full | Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report |
| title_fullStr | Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report |
| title_full_unstemmed | Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report |
| title_short | Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report |
| title_sort | primary uterine diffuse large b cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas a case report |
| topic | Immunocytochemistry; lymphoma; urinary bladder; urine; uterine cervix |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2015;volume=32;issue=3;spage=181;epage=183;aulast=Adachi |
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