Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma
Tumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval is available. The aim of this study was to analyze the recurrence pattern, detection method and associated parameters for possible risk stratification. Histopathological and epidemiolo...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7061 |
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| author | Sebastian Blatt Maximilian Krüger Kawe Sagheb Marie Barth Peer W. Kämmerer Bilal Al-Nawas Keyvan Sagheb |
| author_facet | Sebastian Blatt Maximilian Krüger Kawe Sagheb Marie Barth Peer W. Kämmerer Bilal Al-Nawas Keyvan Sagheb |
| author_sort | Sebastian Blatt |
| collection | DOAJ |
| description | Tumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval is available. The aim of this study was to analyze the recurrence pattern, detection method and associated parameters for possible risk stratification. Histopathological and epidemiological features were obtained retrospectively and correlated with tumor recurrence and overall survival, distant and lymph node metastases. A total of 760 patients were included, of which 216 patients showed tumor recurrence (mean after 24 ± 26 months). Within the first 12 months, 24% of the recurrences were detected. The primary detection method was clinical examination (<i>n</i> = 123, 57%). Tumor recurrence significantly correlated with advanced histopathological grading (G2/3 vs. G1, <i>p</i> < 0.000) and lymph node metastasis (<i>p</i> = 0.004). Tumor recurrence was frequent. Clinical examination was the primary detection method and manifestation within the first 6–12 months was high. The degree of histopathological grading may be useful for risk stratification. |
| first_indexed | 2024-03-09T17:44:06Z |
| format | Article |
| id | doaj.art-fd2ecc19ed9042e1864a7d5dae6eb506 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:44:06Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fd2ecc19ed9042e1864a7d5dae6eb5062023-11-24T11:22:16ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123706110.3390/jcm11237061Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell CarcinomaSebastian Blatt0Maximilian Krüger1Kawe Sagheb2Marie Barth3Peer W. Kämmerer4Bilal Al-Nawas5Keyvan Sagheb6Department of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Prosthetic Dentistry, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyDepartment of Oral- and Maxillofacial Surgery—Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, GermanyTumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval is available. The aim of this study was to analyze the recurrence pattern, detection method and associated parameters for possible risk stratification. Histopathological and epidemiological features were obtained retrospectively and correlated with tumor recurrence and overall survival, distant and lymph node metastases. A total of 760 patients were included, of which 216 patients showed tumor recurrence (mean after 24 ± 26 months). Within the first 12 months, 24% of the recurrences were detected. The primary detection method was clinical examination (<i>n</i> = 123, 57%). Tumor recurrence significantly correlated with advanced histopathological grading (G2/3 vs. G1, <i>p</i> < 0.000) and lymph node metastasis (<i>p</i> = 0.004). Tumor recurrence was frequent. Clinical examination was the primary detection method and manifestation within the first 6–12 months was high. The degree of histopathological grading may be useful for risk stratification.https://www.mdpi.com/2077-0383/11/23/7061oral cancerprognosissquamous cell carcinomarecurrence intervaldifferentiation |
| spellingShingle | Sebastian Blatt Maximilian Krüger Kawe Sagheb Marie Barth Peer W. Kämmerer Bilal Al-Nawas Keyvan Sagheb Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma Journal of Clinical Medicine oral cancer prognosis squamous cell carcinoma recurrence interval differentiation |
| title | Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma |
| title_full | Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma |
| title_fullStr | Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma |
| title_short | Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma |
| title_sort | tumor recurrence and follow up intervals in oral squamous cell carcinoma |
| topic | oral cancer prognosis squamous cell carcinoma recurrence interval differentiation |
| url | https://www.mdpi.com/2077-0383/11/23/7061 |
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