Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain
Oligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin plasticity, and for myelin repair following a demyelinating injury in the adult mammalian brain. Neural stem cells are an important source of oligodendrocytes in the adult brain; however, there are considerable...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2101 |
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| author | Daniel Z. Radecki Jayshree Samanta |
| author_facet | Daniel Z. Radecki Jayshree Samanta |
| author_sort | Daniel Z. Radecki |
| collection | DOAJ |
| description | Oligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin plasticity, and for myelin repair following a demyelinating injury in the adult mammalian brain. Neural stem cells are an important source of oligodendrocytes in the adult brain; however, there are considerable differences in oligodendrogenesis from neural stem cells residing in different areas of the adult brain. Amongst the distinct niches containing neural stem cells, the subventricular zone lining the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus are considered the principle areas of adult neurogenesis. In addition to these areas, radial glia-like cells, which are the precursors of neural stem cells, are found in the lining of the third ventricle, where they are called tanycytes, and in the cerebellum, where they are called Bergmann glia. In this review, we will describe the contribution and regulation of each of these niches in adult oligodendrogenesis. |
| first_indexed | 2024-03-09T22:01:09Z |
| format | Article |
| id | doaj.art-fd30873f61d44f22a09b2b2813f8c092 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:09Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fd30873f61d44f22a09b2b2813f8c0922023-11-23T19:49:31ZengMDPI AGCells2073-44092022-07-011113210110.3390/cells11132101Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian BrainDaniel Z. Radecki0Jayshree Samanta1Department of Comparative Biosciences, School of Veterinary Medicine, Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, School of Veterinary Medicine, Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53706, USAOligodendrogenesis is essential for replacing worn-out oligodendrocytes, promoting myelin plasticity, and for myelin repair following a demyelinating injury in the adult mammalian brain. Neural stem cells are an important source of oligodendrocytes in the adult brain; however, there are considerable differences in oligodendrogenesis from neural stem cells residing in different areas of the adult brain. Amongst the distinct niches containing neural stem cells, the subventricular zone lining the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus are considered the principle areas of adult neurogenesis. In addition to these areas, radial glia-like cells, which are the precursors of neural stem cells, are found in the lining of the third ventricle, where they are called tanycytes, and in the cerebellum, where they are called Bergmann glia. In this review, we will describe the contribution and regulation of each of these niches in adult oligodendrogenesis.https://www.mdpi.com/2073-4409/11/13/2101oligodendrocyteoligodendrogenesisadult neural stem cellsubventricular zonesubgranular zonetanycyte |
| spellingShingle | Daniel Z. Radecki Jayshree Samanta Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain Cells oligodendrocyte oligodendrogenesis adult neural stem cell subventricular zone subgranular zone tanycyte |
| title | Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain |
| title_full | Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain |
| title_fullStr | Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain |
| title_full_unstemmed | Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain |
| title_short | Endogenous Neural Stem Cell Mediated Oligodendrogenesis in the Adult Mammalian Brain |
| title_sort | endogenous neural stem cell mediated oligodendrogenesis in the adult mammalian brain |
| topic | oligodendrocyte oligodendrogenesis adult neural stem cell subventricular zone subgranular zone tanycyte |
| url | https://www.mdpi.com/2073-4409/11/13/2101 |
| work_keys_str_mv | AT danielzradecki endogenousneuralstemcellmediatedoligodendrogenesisintheadultmammalianbrain AT jayshreesamanta endogenousneuralstemcellmediatedoligodendrogenesisintheadultmammalianbrain |