Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma
Abstract Here, we aimed to study the important cytokines in plasma to identify the aldosterone-producing adenoma (APA). 19 unilateral primary aldosteronism (UPA) patients and 19 healthy people were divided into UPA group and Control group, and the serum of bilateral adrenal veins and inferior vena c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32558-9 |
| _version_ | 1797850139283423232 |
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| author | Fei Qin Hong Wen Xiaoge Zhong Yajin Pan Xiaomei Lai Tingting Yang Jing Huang Jie Yu Jianling Li |
| author_facet | Fei Qin Hong Wen Xiaoge Zhong Yajin Pan Xiaomei Lai Tingting Yang Jing Huang Jie Yu Jianling Li |
| author_sort | Fei Qin |
| collection | DOAJ |
| description | Abstract Here, we aimed to study the important cytokines in plasma to identify the aldosterone-producing adenoma (APA). 19 unilateral primary aldosteronism (UPA) patients and 19 healthy people were divided into UPA group and Control group, and the serum of bilateral adrenal veins and inferior vena cava collected by adrenal blood sampling (AVS) in UPA patients and the serum from the healthy subjects were all used to detect multiple cytokines by Luminex immunoassays. Additionally, The UPA patients subjected to laparoscopic adrenalectomy were divided into different groups by pathological results for further study. According our results, IP-10, CXCL9 and RANTES were significantly higher in UPA group compared with control group, and the combination of the three cytokines have significant predictive power for predicting UPA, while the correlational analyses demonstrated that IP-10 and CXCL9 were positively correlated with BP and HR, while EGF was positively correlated with HDL. Additionally, IL-1b was suggested to be the most potential diagnostic biomarker to discriminate the APA and unilateral adrenal hyperplasia (UAH). The present findings might suggest a possibility of IP-10, CXCL9 and RANTES served as a sign to help UPA diagnosis and finally used to assist the diagnosis of APA, while IL-1b was suggested to be the most potential diagnostic biomarker to identify the APA from the UAH patients. |
| first_indexed | 2024-04-09T18:55:33Z |
| format | Article |
| id | doaj.art-fd317715be374909b3773e4992a2344b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T18:55:33Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fd317715be374909b3773e4992a2344b2023-04-09T11:14:51ZengNature PortfolioScientific Reports2045-23222023-04-0113111110.1038/s41598-023-32558-9Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenomaFei Qin0Hong Wen1Xiaoge Zhong2Yajin Pan3Xiaomei Lai4Tingting Yang5Jing Huang6Jie Yu7Jianling Li8Department of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical UniversityAbstract Here, we aimed to study the important cytokines in plasma to identify the aldosterone-producing adenoma (APA). 19 unilateral primary aldosteronism (UPA) patients and 19 healthy people were divided into UPA group and Control group, and the serum of bilateral adrenal veins and inferior vena cava collected by adrenal blood sampling (AVS) in UPA patients and the serum from the healthy subjects were all used to detect multiple cytokines by Luminex immunoassays. Additionally, The UPA patients subjected to laparoscopic adrenalectomy were divided into different groups by pathological results for further study. According our results, IP-10, CXCL9 and RANTES were significantly higher in UPA group compared with control group, and the combination of the three cytokines have significant predictive power for predicting UPA, while the correlational analyses demonstrated that IP-10 and CXCL9 were positively correlated with BP and HR, while EGF was positively correlated with HDL. Additionally, IL-1b was suggested to be the most potential diagnostic biomarker to discriminate the APA and unilateral adrenal hyperplasia (UAH). The present findings might suggest a possibility of IP-10, CXCL9 and RANTES served as a sign to help UPA diagnosis and finally used to assist the diagnosis of APA, while IL-1b was suggested to be the most potential diagnostic biomarker to identify the APA from the UAH patients.https://doi.org/10.1038/s41598-023-32558-9 |
| spellingShingle | Fei Qin Hong Wen Xiaoge Zhong Yajin Pan Xiaomei Lai Tingting Yang Jing Huang Jie Yu Jianling Li Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma Scientific Reports |
| title | Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma |
| title_full | Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma |
| title_fullStr | Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma |
| title_full_unstemmed | Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma |
| title_short | Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma |
| title_sort | diagnostic accuracy of using multiple cytokines to predict aldosterone producing adenoma |
| url | https://doi.org/10.1038/s41598-023-32558-9 |
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