Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates i...

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Bibliographic Details
Main Authors: Leonardo Gomes Braga Ferreira, Valber da Silva Frutuoso, Robson Xavier Faria, Rômulo José Soares Bezerra, Luiz Anastacio Alves
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
P2X7R
inflammatory response
antagonists and pharmacological target
Online Access:http://www.mdpi.com/1420-3049/18/9/10953

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