Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth
<p> <b>G.F. Proklova<sup>1</sup>, R.A. Chilova<sup>1</sup>, E.A. Sokova<sup>2</sup>, R.E. Kazakov<sup>2</sup>, E.V. Zhukova<sup>1</sup>, K.O. Akopov<sup>3</sup>, N.S. Trifonova<sup>1</sup></b> <...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LCC «Medicine-Inform»
2020-09-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/189/189d2ad7c3acba9b9edac69763c1df3a.pdf |
| _version_ | 1797294952695201792 |
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| author | G.F. Proklova Chilova R.A. E.A. Sokova R.E. Kazakov E.V. Zhukova N.S. Trifonova |
| author_facet | G.F. Proklova Chilova R.A. E.A. Sokova R.E. Kazakov E.V. Zhukova N.S. Trifonova |
| author_sort | G.F. Proklova |
| collection | DOAJ |
| description | <p>
<b>G.F. Proklova<sup>1</sup>, R.A. Chilova<sup>1</sup>, E.A. Sokova<sup>2</sup>, R.E. Kazakov<sup>2</sup>, E.V. Zhukova<sup>1</sup>, K.O. Akopov<sup>3</sup>, N.S. Trifonova<sup>1</sup></b>
</p>
<p>
<b><sup>1</sup>I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, <br>
Russian Federation</b>
</p>
<p>
<b><sup>2</sup>Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russian Federation</b>
</p>
<p>
<b><sup>3</sup>S.S. Yudin City Clinical Hospital, Moscow, Russian Federation</b>
</p>
<p>
<i>This paper reviews the effects of ADRB2 gene polymorphism on the efficacy of tocolytic therapy in preterm birth. Statistically, prematurity accounts for 70% to 75% of neonatal and infant mortality while stillbirths are 13 times more common in preterm birth compared to full-term birth. Despite modern diagnostic and treatment options to manage threatened preterm labor, its rate does not reduce. Meanwhile, pregnancy prolongation even by 48 hours is often enough to prevent newborn respiratory distress syndrome thereby improving perinatal outcomes, saving many lives of preterm babies, and preventing disability. That is why it is so important to initiate early maximally efficient and safe for a fetus tocolytic therapy aimed at prolonging the pregnancy. It was demonstrated that individual genetic variations determining intranatal phenotype exist. However, the associations between genetic characteristics and the rate of labor activity were currently demonstrated only for single genes. This is particularly true for a gene encoding </i>β<i><sub>2</sub>-adrenergic receptors whose stimulation in the uterus and cervix by endogenous and exogenous agonists relaxes smooth muscles.</i>
</p>
<p>
<i><b>Keywords</b>: preterm birth, perinatal outcome, tocolytic therapy, ADRB2 gene polymorphism, </i>β<i><sub>2</sub>-adrenergic receptors, single nucleotide polymorphism.</i>
</p>
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<i><b>For citation:</b> Proklova G.F., Chilova R.A., Sokova E.A. et al. Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with</i> β<i><sub>2</sub>-adrenergic agonists in preterm birth. Russian Journal of Woman and Child Health. 2020;3(3):194–197. DOI: 10.32364/2618-8430-2020-3-3-194-197.</i>
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| first_indexed | 2024-03-07T21:39:05Z |
| format | Article |
| id | doaj.art-fd3757306e19491a91d02247635853a8 |
| institution | Directory Open Access Journal |
| issn | 2618-8430 2686-7184 |
| language | Russian |
| last_indexed | 2024-03-07T21:39:05Z |
| publishDate | 2020-09-01 |
| publisher | LCC «Medicine-Inform» |
| record_format | Article |
| series | РМЖ. Мать и дитя |
| spelling | doaj.art-fd3757306e19491a91d02247635853a82024-02-26T10:13:32ZrusLCC «Medicine-Inform»РМЖ. Мать и дитя2618-84302686-71842020-09-013333094Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birthG.F. Proklova0Chilova R.A.1E.A. Sokova2R.E. Kazakov3E.V. Zhukova45N.S. Trifonova6Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> <b>G.F. Proklova<sup>1</sup>, R.A. Chilova<sup>1</sup>, E.A. Sokova<sup>2</sup>, R.E. Kazakov<sup>2</sup>, E.V. Zhukova<sup>1</sup>, K.O. Akopov<sup>3</sup>, N.S. Trifonova<sup>1</sup></b> </p> <p> <b><sup>1</sup>I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, <br> Russian Federation</b> </p> <p> <b><sup>2</sup>Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russian Federation</b> </p> <p> <b><sup>3</sup>S.S. Yudin City Clinical Hospital, Moscow, Russian Federation</b> </p> <p> <i>This paper reviews the effects of ADRB2 gene polymorphism on the efficacy of tocolytic therapy in preterm birth. Statistically, prematurity accounts for 70% to 75% of neonatal and infant mortality while stillbirths are 13 times more common in preterm birth compared to full-term birth. Despite modern diagnostic and treatment options to manage threatened preterm labor, its rate does not reduce. Meanwhile, pregnancy prolongation even by 48 hours is often enough to prevent newborn respiratory distress syndrome thereby improving perinatal outcomes, saving many lives of preterm babies, and preventing disability. That is why it is so important to initiate early maximally efficient and safe for a fetus tocolytic therapy aimed at prolonging the pregnancy. It was demonstrated that individual genetic variations determining intranatal phenotype exist. However, the associations between genetic characteristics and the rate of labor activity were currently demonstrated only for single genes. This is particularly true for a gene encoding </i>β<i><sub>2</sub>-adrenergic receptors whose stimulation in the uterus and cervix by endogenous and exogenous agonists relaxes smooth muscles.</i> </p> <p> <i><b>Keywords</b>: preterm birth, perinatal outcome, tocolytic therapy, ADRB2 gene polymorphism, </i>β<i><sub>2</sub>-adrenergic receptors, single nucleotide polymorphism.</i> </p> <p> <i><b>For citation:</b> Proklova G.F., Chilova R.A., Sokova E.A. et al. Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with</i> β<i><sub>2</sub>-adrenergic agonists in preterm birth. Russian Journal of Woman and Child Health. 2020;3(3):194–197. DOI: 10.32364/2618-8430-2020-3-3-194-197.</i> </p> <i><br> </i><br>http://wchjournal.com/upload/iblock/189/189d2ad7c3acba9b9edac69763c1df3a.pdf |
| spellingShingle | G.F. Proklova Chilova R.A. E.A. Sokova R.E. Kazakov E.V. Zhukova N.S. Trifonova Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth РМЖ. Мать и дитя |
| title | Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth |
| title_full | Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth |
| title_fullStr | Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth |
| title_full_unstemmed | Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth |
| title_short | Effect of ADRB gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth |
| title_sort | effect of adrb gene polymorphism on the efficacy and safety of tocolytic therapy with β2 adrenergic agonists in preterm birth |
| url | http://wchjournal.com/upload/iblock/189/189d2ad7c3acba9b9edac69763c1df3a.pdf |
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