Tumour‐associated macrophages in gastric cancer: From function and mechanism to application
Abstract Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evide...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | https://doi.org/10.1002/ctm2.1386 |
| _version_ | 1797677792508248064 |
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| author | Jie Li Juan Sun Ziyang Zeng Zhen Liu Mingwei Ma Zicheng Zheng Yixuan He Weiming Kang |
| author_facet | Jie Li Juan Sun Ziyang Zeng Zhen Liu Mingwei Ma Zicheng Zheng Yixuan He Weiming Kang |
| author_sort | Jie Li |
| collection | DOAJ |
| description | Abstract Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour‐associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME. Main body In this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with the microbial community are summarised. Although the role of TAMs in GC remains controversial in clinical settings, clarifying their significance in the treatment selection and prognostic prediction of GC could support optimising TAM‐centred clinicaltherapy. Conclusion In summary, we reviewed the the phenotypic polarisation, function and molecular mechanism of TAMs and their potential applications in the treatment selection and prognostic prediction of GC. |
| first_indexed | 2024-03-11T22:49:20Z |
| format | Article |
| id | doaj.art-fd37637f57984a2d84ca3cefb87703b0 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-03-11T22:49:20Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-fd37637f57984a2d84ca3cefb87703b02023-09-22T04:05:54ZengWileyClinical and Translational Medicine2001-13262023-08-01138n/an/a10.1002/ctm2.1386Tumour‐associated macrophages in gastric cancer: From function and mechanism to applicationJie Li0Juan Sun1Ziyang Zeng2Zhen Liu3Mingwei Ma4Zicheng Zheng5Yixuan He6Weiming Kang7Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaDepartment of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing People's Republic of ChinaAbstract Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour‐associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME. Main body In this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with the microbial community are summarised. Although the role of TAMs in GC remains controversial in clinical settings, clarifying their significance in the treatment selection and prognostic prediction of GC could support optimising TAM‐centred clinicaltherapy. Conclusion In summary, we reviewed the the phenotypic polarisation, function and molecular mechanism of TAMs and their potential applications in the treatment selection and prognostic prediction of GC.https://doi.org/10.1002/ctm2.1386gastric cancerimmune infiltrationmacrophage polarisationprognostic predictiontumour‐associated macrophage |
| spellingShingle | Jie Li Juan Sun Ziyang Zeng Zhen Liu Mingwei Ma Zicheng Zheng Yixuan He Weiming Kang Tumour‐associated macrophages in gastric cancer: From function and mechanism to application Clinical and Translational Medicine gastric cancer immune infiltration macrophage polarisation prognostic prediction tumour‐associated macrophage |
| title | Tumour‐associated macrophages in gastric cancer: From function and mechanism to application |
| title_full | Tumour‐associated macrophages in gastric cancer: From function and mechanism to application |
| title_fullStr | Tumour‐associated macrophages in gastric cancer: From function and mechanism to application |
| title_full_unstemmed | Tumour‐associated macrophages in gastric cancer: From function and mechanism to application |
| title_short | Tumour‐associated macrophages in gastric cancer: From function and mechanism to application |
| title_sort | tumour associated macrophages in gastric cancer from function and mechanism to application |
| topic | gastric cancer immune infiltration macrophage polarisation prognostic prediction tumour‐associated macrophage |
| url | https://doi.org/10.1002/ctm2.1386 |
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