Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus

Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus

Seasonal H3N2 influenza evolves rapidly, leading to an extremely poor vaccine efficacy. Substitutions employed during vaccine production using embryonated eggs (i.e., egg passage adaptation) contribute to the poor vaccine efficacy (VE), but the evolutionary mechanism remains elusive. Using an unprec...

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Bibliographic Details
Main Authors: Yunsong Liu, Hui Chen, Wenyuan Duan, Xinyi Zhang, Xionglei He, Rasmus Nielsen, Liang Ma, Weiwei Zhai
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Viruses
Subjects:
H3N2 influenza
passage adaptation
vaccine efficacy
epistasis
fitness landscape
convergent evolution
Online Access:https://www.mdpi.com/1999-4915/14/9/2065

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