Multiparametric Analysis of Longitudinal Quantitative MRI Data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer

Multiparametric Analysis of Longitudinal Quantitative MRI Data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer

This study identifies physiological tumor habitats from quantitative magnetic resonance imaging (MRI) data and evaluates their alterations in response to therapy. Two models of breast cancer (BT-474 and MDA-MB-231) were imaged longitudinally with diffusion-weighted MRI and dynamic contrast-enhanced...

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Bibliographic Details
Main Authors: Anum K. Syed, Jennifer G. Whisenant, Stephanie L. Barnes, Anna G. Sorace, Thomas E. Yankeelov
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
diffusion-weighted MRI
dynamic contrast-enhanced MRI
immunohistochemistry
habitat imaging
intratumoral heterogeneity
Online Access:https://www.mdpi.com/2072-6694/12/6/1682

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