A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence
A one-pot two-step reaction of 2-(trifluoromethyl)-2-hydroxy-2H-chromene with aryl ketone afforded α-trifluoromethylated tertiary alcohols bearing coumarins. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with CH3COOH and NH4OAc in one-pot proces...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610322001600 |
| _version_ | 1797946404826513408 |
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| author | Lulu Wu Zhenliang Pan Liangxin Fan Guoyu Yang Lijun Shi Shengfei Jiang Xiaodan Chang Bingyi Zhou Yanyan Yang Cuilian Xu Caixia Wang |
| author_facet | Lulu Wu Zhenliang Pan Liangxin Fan Guoyu Yang Lijun Shi Shengfei Jiang Xiaodan Chang Bingyi Zhou Yanyan Yang Cuilian Xu Caixia Wang |
| author_sort | Lulu Wu |
| collection | DOAJ |
| description | A one-pot two-step reaction of 2-(trifluoromethyl)-2-hydroxy-2H-chromene with aryl ketone afforded α-trifluoromethylated tertiary alcohols bearing coumarins. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with CH3COOH and NH4OAc in one-pot process. The reaction proceeded to give the title compounds in moderate to good yields. |
| first_indexed | 2024-04-10T21:10:30Z |
| format | Article |
| id | doaj.art-fd3c9a4978a94f4ab5dfc4d03c2eb492 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-10T21:10:30Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-fd3c9a4978a94f4ab5dfc4d03c2eb4922023-01-21T04:20:17ZengElsevierJournal of Saudi Chemical Society1319-61032023-01-01271101578A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequenceLulu Wu0Zhenliang Pan1Liangxin Fan2Guoyu Yang3Lijun Shi4Shengfei Jiang5Xiaodan Chang6Bingyi Zhou7Yanyan Yang8Cuilian Xu9Caixia Wang10College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Tobacco, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR ChinaCollege of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China; Corresponding authors.College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China; Corresponding authors.A one-pot two-step reaction of 2-(trifluoromethyl)-2-hydroxy-2H-chromene with aryl ketone afforded α-trifluoromethylated tertiary alcohols bearing coumarins. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with CH3COOH and NH4OAc in one-pot process. The reaction proceeded to give the title compounds in moderate to good yields.http://www.sciencedirect.com/science/article/pii/S1319610322001600CoumarinsTrifluoromethylTertiary alcoholsOne-pot approach |
| spellingShingle | Lulu Wu Zhenliang Pan Liangxin Fan Guoyu Yang Lijun Shi Shengfei Jiang Xiaodan Chang Bingyi Zhou Yanyan Yang Cuilian Xu Caixia Wang A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence Journal of Saudi Chemical Society Coumarins Trifluoromethyl Tertiary alcohols One-pot approach |
| title | A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence |
| title_full | A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence |
| title_fullStr | A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence |
| title_full_unstemmed | A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence |
| title_short | A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence |
| title_sort | one pot approach to novel α trifluoromethylated coumarin bearing tertiary alcohols promoted by ch3cooh nh4oac via consecutive ring opening aldol sequence |
| topic | Coumarins Trifluoromethyl Tertiary alcohols One-pot approach |
| url | http://www.sciencedirect.com/science/article/pii/S1319610322001600 |
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