A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence

A one-pot approach to novel α-trifluoromethylated coumarin-bearing tertiary alcohols promoted by CH3COOH/NH4OAc via consecutive ring-opening/aldol sequence

A one-pot two-step reaction of 2-(trifluoromethyl)-2-hydroxy-2H-chromene with aryl ketone afforded α-trifluoromethylated tertiary alcohols bearing coumarins. The atomic economic and simply manipulative reaction involved premier treatment of reaction mixtures with CH3COOH and NH4OAc in one-pot proces...

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Bibliographic Details
Main Authors: Lulu Wu, Zhenliang Pan, Liangxin Fan, Guoyu Yang, Lijun Shi, Shengfei Jiang, Xiaodan Chang, Bingyi Zhou, Yanyan Yang, Cuilian Xu, Caixia Wang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Coumarins
Trifluoromethyl
Tertiary alcohols
One-pot approach
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610322001600

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