O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype

O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype

Abstract O‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in the establishment and maintenance of cell polarity, because mice lacking O‐GlcNAc transferase (OGT) are e...

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Bibliographic Details
Main Authors: Fan Yu, Song Yang, Hua Ni, Dai Heng, Xuemei Wu, Mulin Yang, Xinming Zhang, Yuxin Cao, Yandong Pei, Di An, Dengwen Li, Dayong Liu, Lin Liu, Leiting Pan, Quan Chen, Xueliang Zhu, Jun Zhou
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
cell polarity
centrosome
microtubule
O‐GlcNAcylation
phase separation
pulmonary fibrosis
Online Access:https://doi.org/10.1002/advs.202303545

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